Follow us on Twitter Visit us on Tumblr Visit us on Facebook Visit us on YouTube

Medical Sciences


The 2014-15 membership of this committee has not yet been finalized. Complete membership information for 2014-15 will be posted as soon as it becomes available.

Faculty of the Committee on Higher Degrees in Medical Sciences

David E. Golan, Dean for Graduate Education, Professor of Biological Chemistry and Molecular Pharmacology, George R. Minot Professor of Medicine (Medical School) (Chair)

Other Faculty Offering Instruction in the Division of Medical Sciences

The Division of Medical Sciences makes available to graduate students the facilities of the preclinical departments and research laboratories of the Harvard Medical School and its affiliated hospitals and institutions. The Division offers advanced courses and research in cell biology, biological chemistry and molecular pharmacology, genetics, immunology, microbiology and molecular genetics, neurosciences, pathology, physiology, and virology. Qualified undergraduates may be admitted with the permission of the instructor and the student’s department of concentration, as far as the facilities of the special laboratories permit. Inquiries should be addressed to the Division of Medical Sciences, Harvard Medical School, 260 Longwood Avenue, Boston, MA 02115, or telephone (617) 432-0162, email address dms@hms.harvard.edu.

For other courses in biological sciences, see listings of the Program in Biological Sciences in Public Health, Biophysics and Molecular and Cellular Biology.

Biological and Biomedical Sciences (BBS)

BBS is an interdepartmental graduate training program in cellular and molecular biology. BBS faculty members are drawn from all of the basic science departments of Harvard Medical School — Biological Chemistry and Molecular Pharmacology (BCMP), Cell Biology, Stem Cell and Regenerative Biology, Genetics, Microbiology and Immunobiology, Neurobiology and Systems Biology — and from many of Harvard’s affiliated teaching hospitals. BBS has also incorporated faculty from the Faculty of Arts and Sciences (FAS) as part of its effort to build new initiatives in graduate training.

Primarily for Graduates

BBS 230 (formerly Microbiology 230). Analysis of the Biological Literature
Catalog Number: 36968
Michael Demian Blower (Medical School), Dipanjan Chowdhury (Medical School), Stephen J. Elledge (Medical School), Jonathan M. G. Higgins (Medical School), Cammie Lesser (Medical School), Adrian Salic (Medical School), Andreas Herrlich (Medical School), Laurie Jackson-Grusby (Medical School)
Half course (fall term). Tu., Th., 3-6. EXAM GROUP: 2
Students participate in intensive small group discussions focused on the critical analysis of basic research papers from a wide range of fields including biochemistry, cell and developmental biology, genetics, and microbiology. Papers are discussed in terms of their background, significance, hypothesis, experimental methods, data quality, and interpretation of results. Students will be asked to propose future research directions, to generate new hypotheses and to design experiments aimed at testing them.
Note: This course is required for first year BBS students. Students who are not first year BBS are welcome to contact the course director to determine if space is available and receive course materials in advance of class. For the midterm and final exams the students will be asked to submit written critiques of recent papers from the literature, with an emphasis on proposing new experimental directions to test the models proposed in the papers.

Graduate Courses of Reading and Research

*BBS 301. Teaching Practicum
Catalog Number: 77888
David L. Van Vactor (Medical School) 2089 and members of the Departments
Half course (fall term). Hours to be arranged.
Course for TAs currently teaching in an approved BBS Core Course. The embedded teaching practicum provides practice-based training in facilitating a group discussion; professionalism in the classroom; curriculum design, course evaluation and assessment development; and preparation for teaching throughout and beyond time in graduate school. Teaching assistants are provided training and experience in the development of an early-career teaching philosophy.
Note: TAs should contact Jason Heustis.

BBS 330 (formerly Genetics 330). Critical Thinking and Research Proposal Writing
Catalog Number: 14711
Monica P. Colaiácovo (Medical School) 4949 and members of the Medical School
Half course (fall term). Hours to be arranged.
A small group tutorial systematically guiding students in the writing of original, hypothesis-driven research proposals from initial topic selection through completion of a final draft.
Note: This course is required for second year BBS students; others need permission of the instructor. Dates, times and locations for all sessions, following the first meeting, will be coordinated between each group of students and the pair of faculty members guiding these sessions. Group assignments will be posted on the course website following the first meeting.

*BBS 333r. Introduction to Research in Biological and Biomedical Sciences
Catalog Number: 1206
Susan M. Dymecki (Medical School) 1736
Note: BBS students register for lab rotations under this course number.

*BBS 380. Reading and Research in Biological and Biomedical Sciences
Catalog Number: 0349
David L. Van Vactor (Medical School) 2089

Biological Chemistry and Molecular Pharmacology

All courses in Biological Chemistry and Molecular Pharmacology are subject to limitation in enrollment and will not be offered unless there is sufficient demand. For courses in Neuropharmacology, see listings under Neurobiology. For more courses in biochemistry, see other listings in the FAS Biological Sciences section.

Primarily for Graduates

BCMP 200. Molecular Biology
Catalog Number: 5591
Joseph John Loparo (Medical School), Paul J. Anderson (Medical School), Lee Stirling Churchman (Medical School), Johannes Walter (Medical School), and Timur Yusufzai (Medical School)
Half course (fall term). M., W., F., 10:45-12:15. EXAM GROUP: 5
An advanced treatment of molecular biology’s Central Dogma. Considers the molecular basis of information transfer from DNA to RNA to protein, using examples from eukaryotic and prokaryotic systems. Lectures, discussion groups, and research seminars.
Note: Offered jointly with the Medical School as BP 723.0.
Prerequisite: Intended primarily for graduate students familiar with basic molecular biology or with strong biology/chemistry background.

BCMP 201. Biological Macromolecules: Structure, Function and Pathways
Catalog Number: 5068
Stephen C. Harrison (Medical School), Stephen C. Blacklow (Medical School), and Peter K. Sorger (Medical School)
Half course (spring term). Tu., Th., 9:30–11, W., 4–5:30. EXAM GROUP: 2
Macromolecular structure with emphasis on biochemistry, interactions and catalysis in cellular processes and pathways. Links between theory and observation will emerge from discussion of fundamental principles, computational approaches and experimental methods.
Note: The course is intended for all Division of Medical Sciences (DMS) graduate students and is open to advanced undergraduates. Offered jointly with the Medical School as BP 714.0.

*BCMP 213. Behavioral Pharmacology
Catalog Number: 4782 Enrollment: Limited to 15.
Jack Bergman (Medical School) and Brian D. Kangas (Medical School)
Half course (spring term). Hours to be arranged. EXAM GROUP: 16
Introduction to behavioral pharmacology of CNS drugs (e.g., psychomotor stimulants, antischizophrenics, opioid analgesics, antianxiety agents); seminar format with emphasis on behavioral methodology (i.e., model and assay development) and pharmacological analysis (i.e., receptor selectivity and efficacy); attention to tolerance, drug dependence/addiction/treatment, and basic behavioral processes.
Note: Offered jointly with the Medical School as BP 719.0.

*BCMP 218. Molecular Medicine
Catalog Number: 2049 Enrollment: Limited to 35.
George Q. Daley (Medical School), David E. Cohen (Medical School), and Irving M. London (Medical School)
Half course (fall term). Tu., 1–3. EXAM GROUP: 8
A seminar on various human diseases and their underlying genetic or biochemical bases. Primary scientific papers discussed. Lectures by faculty and seminars conducted by students, faculty supervision.
Note: Faculty mentors will guide student-led discussions of the papers. Jointly offered with the Medical School as HT 140.
Prerequisite: Molecular Biology and Biochemistry.

BCMP 228. Macromolecular NMR
Catalog Number: 3969
Gerhard Wagner (Medical School), James J. Chou (Medical School), Haribabu Arthanari (Medical School), Kirill Oxenoid (Medical School) and members of the NMR lab
Half course (fall term). M., F., 2–3:30. EXAM GROUP: 7
Theory and practice of modern methods of macromolecular structure determination using multi-dimensional NMR.
Note: Given in alternate years. Offered jointly with the Medical School as BP 722.0. Classroom lectures on Mondays and Fridays. The course will include classroom lectures, practical training and hands-on problem solving. The latter includes basic aspects of spectrometer operation, computer-based assignment of protein NMR spectra and structure calculation.

BCMP 230. Principles and Practice of Drug Development
Catalog Number: 1295
Stan Neil Finkelstein (Medical School) and Robert H. Rubin (Medical School)
Half course (fall term). Th., 3–6. EXAM GROUP: 2
Critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules. Economic considerations of the drug development process.
Note: Classes held at MIT.

BCMP 234. Cellular Metabolism and Human Disease
Catalog Number: 9644 Enrollment: May be limited
Thomas Michel (Medical School), Cheryl Denise Vaughan and members of the Department
Half course (spring term). M., W., F., 9-10:30. EXAM GROUP: 10
Cellular and organismal metabolism, with focus on interrelationships between key metabolic pathways and human disease states. Genetic and acquired metabolic diseases and functional consequences. Interactive lectures and critical reading conferences are integrated with clinical encounters.
Note: Also listed as MCB 234.
Prerequisite: Knowledge of introductory biochemistry, genetics, and cell biology required (MCB 52 and 54 or equivalent); one year of organic chemistry.

BCMP 236. Modern Drug Discovery: from principles to patients
Catalog Number: 84345
Nathanael Gray (Medical School), Timothy J. Mitchison (Medical School) and members of the Department
Half course (spring term). Tu., Th., 3:30–5. EXAM GROUP: 16
This course will familiarize students with central concepts in drug action and therapeutics at the level of molecules, cells, tissues and patients. These concepts and methods are central to modern drug development and regulatory evaluation. In the 1st half of the course we will cover drug-target interactions, Pharmacokinetics and Pharmacodynamics at a quantitative level, the clinical trials process, biomarkers and new frontiers in Therapeutic development. The 2nd half will focus on modern approaches to therapeutic discovery and development, both small molecules and protein based. Examples are drawn from numerous unmet medical needs including cancer, HIV, neurodegenerative and infectious diseases. The course will include computational exercises and a MATLAB workshop.
Note: This course is the combination of the BCMP 309qc and 307qc quarter courses, offered as half course. Students who plan to take the two quarters must sign up under BCMP 236.

Graduate Courses of Reading and Research

*BCMP 309. Regulation of Membrane Protein and Lipid Dynamics: Molecular Mechanisms and Biological Implications
Catalog Number: 1558
David E. Golan (Medical School) 1558

*BCMP 310. Molecular and Cellular Mechanisms of Insulin Action
Catalog Number: 4299
Morris F. White (Medical School) 3158

*BCMP 311. Structure and Dynamics of Macromolecular Assemblies
Catalog Number: 3623
Stephen C. Harrison (Medical School) 3597

*BCMP 312. Downregulating DNA Repair: Phosphatases & MicroRNAs
Catalog Number: 30165
Dipanjan Chowdhury (Medical School) 6266

*BCMP 313 (formerly Pathology 354). Biochemistry of transmembrane receptors and signaling
Catalog Number: 49628
Stephen C. Blacklow (Medical School) 1462

*BCMP 314. Protein NMR Spectroscopy of Membrane Protein
Catalog Number: 3449
James J. Chou (Medical School) 4950

*BCMP 315. Growth Factor Structure and Function
Catalog Number: 6034
Michael Klagsbrun (Medical School) 3167

*BCMP 316. Signal Transduction and Phosphorylation in Heart Disease
Catalog Number: 96794
Maria Irene Kontaridis (Medical School) 6398

*BCMP 317. Signal Transduction and Related Molecular Pathophysiology
Catalog Number: 3354
Steven E. Shoelson (Medical School) 3951

*BCMP 318. Innate Immunity Against RNA Viruses
Catalog Number: 45272
Sun Hur (Medical School) 6403

*BCMP 319. Histone Variants and Chromosome Biology
Catalog Number: 1748
Kami Ahmad (Medical School) 4592

*BCMP 320. Systems and Synthetic Biology
Catalog Number: 0265
Pamela A. Silver (Medical School) 1595

*BCMP 324. Structure and Replication of DNA
Catalog Number: 5059
Charles C. Richardson (Medical School) 2479

*BCMP 325. Genomic Instability and Cancer Susceptibility
Catalog Number: 4110
Alan D. D’Andrea (Medical School) 3532

*BCMP 328. Computational Analysis of Sequence Variation and Divergence
Catalog Number: 2468
Shamil R. Sunyaev (Medical School) 4671

*BCMP 329. Structure Biology of Cytoplasmic Signal Transduction
Catalog Number: 5005
Michael J. Eck (Medical School) 1739

[*BCMP 330. Critical Thinking and Research Proposal Writing]
Catalog Number: 36741
Monica P. Colaiácovo (Medical School) 4949 and members of the Medical School
Half course (fall term). Hours to be arranged.
A small group tutorial systematically guiding students in the writing of original, hypothesis-driven research proposals from initial topic selection through completion of a final draft.
Note: This course is required for second year BBS students; others need permission of the instructor. Dates, times and locations for all sessions, following the first meeting, will be coordinated between each group of students and the pair of faculty members guiding these sessions. Group assignments will be posted on the course website following the first meeting.

*BCMP 331. Biochemistry and Biology of Neurodegenerative Diseases
Catalog Number: 9727
Michael S. Wolfe (Medical School) 4543

*BCMP 332. Pathophysiologic functions of BMP signaling
Catalog Number: 93159
Paul B. Yu (Medical School) 7432

*BCMP 333. Structural biology of mechanisms in gene regulation
Catalog Number: 95018
Piotr Sliz (Medical School) 6569

*BCMP 334. MicroRNA Functions in Cancers and Quiescence
Catalog Number: 79343
Shobha Vasudevan (Medical School) 6972

*BCMP 335. Biochemical and Genetic Analysis of Eukaryotic Gene Expression
Catalog Number: 8052
Stephen Buratowski (Medical School) 1790

*BCMP 337. Drosophila Molecular Genetics
Catalog Number: 0782
Welcome W. Bender (Medical School) 7083

*BCMP 338. Gene regulation in yeast and cancer
Catalog Number: 0549
Kevin Struhl (Medical School) 7415

*BCMP 340. Biologically Active Small Molecules
Catalog Number: 8300
Jon Clardy (Medical School) 4667

*BCMP 343. Molecular Genetics of Herpes Viruses
Catalog Number: 0868
Donald M. Coen (Medical School) 7617

*BCMP 344. Molecular Pharmacology of Excitable Membranes
Catalog Number: 0200
Gary R. Strichartz (Medical School) 7530

*BCMP 345. Transcription Factors in Hematopoiesis and Leukemogenesis
Catalog Number: 4792
Alan B. Cantor (Medical School) 5150

*BCMP 348. Chromatin and Cancer
Catalog Number: 6409
Charles M. Roberts (Medical School) 5151

*BCMP 349. Targeting Deregulated Apoptotic and Transcriptional Pathways in Cancer
Catalog Number: 1071
Loren D. Walensky (Medical School) 5665

*BCMP 352. Chemical Mediators in Inflammation and Resolution
Catalog Number: 4853
Charles N. Serhan (Medical School) 3163

*BCMP 353. Epigenomics and Chromatin Systems Biology
Catalog Number: 8682
Yujiang Shi (Medical School) 5509

*BCMP 355. Transcriptional Control of Hematopoiesis and Leukemia
Catalog Number: 4489
Hanno Reinhard Hock (Medical School) 5660

*BCMP 356. NMR Spectroscopy of Proteins and Metabolites
Catalog Number: 8093
Gerhard Wagner (Medical School) 2626

*BCMP 358. Targeting Apoptosis Regulation in Cancer
Catalog Number: 6735
Anthony G. Letai (Medical School) 5663

*BCMP 359. Molecular Mechanisms of Signal Transduction
Catalog Number: 8520
Elaine A. Elion (Medical School) 2941

*BCMP 360. Regeneration of Cartilage and Skeletal Muscle
Catalog Number: 6934
Andrew B. Lassar (Medical School) 2946

*BCMP 361. X-Ray Crystallographic Studies of Viruses and Proteins
Catalog Number: 4155
James M. Hogle (Medical School) 2943

*BCMP 362. Eukaryotic Survival Decisions
Catalog Number: 4972
David E. Fisher (Medical School) 1800

*BCMP 363. Normal cell division mechanisms and cell division defects in cancer
Catalog Number: 4981
David Pellman (Medical School) 3702

*BCMP 366. Stem Cells in Disease and Development
Catalog Number: 9236
George Q. Daley (Medical School) 4951

*BCMP 370. Advanced Topics in Biological Chemistry and Molecular Pharmacology
Catalog Number: 0482
David Lopes Cardozo (Medical School) 5995
A series of reading and discussion seminars, each running for a half term (7 weeks). Two seminars, which can be taken in different terms, are required for credit.
Note: Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 617-432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*BCMP 371. Maintenance of genome stability in S phase
Catalog Number: 3739
Johannes Walter (Medical School) 3846

*BCMP 375. Biomolecular Nanotechnology
Catalog Number: 3288
William Shih (Medical School) 5256

*BCMP 376. Mechanisms of Action of Antibiotics
Catalog Number: 3033
Daniel E. Kahne 5065

*BCMP 377. Quantitative Proteomics of Cancer Progression
Catalog Number: 5225
Jarrod Marto (Medical School) 5326

*BCMP 378. Mechanisms of Hepatic Cholesterol Elimination
Catalog Number: 6669
David E. Cohen (Medical School) 3478

*BCMP 379. Biochemical and Molecular Regulation of Vascular Growth
Catalog Number: 9374
Marsha Moses (Medical School) 5388

*BCMP 381. Functional Small Molecules for Biological Discovery
Catalog Number: 8841
Nathanael Gray (Medical School) 5730

*BCMP 382. Mechanisms of RNAi in Stem Cells
Catalog Number: 9601
Richard Ian Gregory (Medical School) 5743

*BCMP 383. Integrated and Functional Genomic Studies of Human Cancer
Catalog Number: 5334
Levi Alexander Garraway (Medical School) 6203

*BCMP 384. Embryonic stem cells, Nuclear Transfer, Cancer, Reprogramming
Catalog Number: 5330
Konrad Hochedlinger (Medical School) 6101

*BCMP 385. Control of Gene Expression in Tumorgenesis and Differentiation
Catalog Number: 59773
Thomas M. Roberts (Medical School) 7729

*BCMP 386. Kinase Signaling in Cancer
Catalog Number: 23358
Jean J. Zhao (Medical School) 6237

*BCMP 387. Single-molecule Biophysics and Force Spectroscopy
Catalog Number: 47527
Wesley Philip Wong (Medical School) 6463

*BCMP 388. Single-molecule studies of DNA repair
Catalog Number: 19862
Joseph John Loparo (Medical School) 6798

*BCMP 389. Chromatin and DNA Dynamics
Catalog Number: 86491
Timur Yusufzai (Medical School) 6953

*BCMP 390. Gene Regulation Studied with Small Molecules
Catalog Number: 87028
James Elliott Bradner (Medical School) 6542

*BCMP 391. Redox biology, trace elements and aging
Catalog Number: 82614
Vadim Gladyshev (Medical School) 3401

Quarter Courses for Graduate Students Only

*BCMP 300qc. Advanced Topics in Biological Chemistry and Molecular Pharmacology
Catalog Number: 69187
David Lopes Cardozo (Medical School) 5995
A series of reading and discussion seminars, each running for a half term (7 weeks).
Note: Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 617-432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*BCMP 301qc. Translational Pharmacology
Catalog Number: 97487 Enrollment: Enrollment may be limited.
Donald M. Coen (Medical School) 7617 and David E. Golan (Medical School)
Quarter course (spring term). Hours to be arranged.
This intensive course held during the first two full weeks of January (ten days) covers principles of pharmacology and their translation into new drug development. Students participate in project groups composed of both graduate students and post-graduate M.D.’s to propose a drug development strategy from target choice through clinical trials. There are two hours of lectures each of the first eight mornings; afternoons include case studies discussed by Harvard faculty and faculty from the pharmaceutical and biotechnology industries, or time to work on the project. Evaluation is based on the project and class participation. Enrollment may be limited.

*BCMP 302qc. Molecular Movies: Introduction to 3D Visualization with Maya
Catalog Number: 45965 Enrollment: Limited to 8. Will accept up to 12 auditors.
David Lopes Cardozo (Medical School) 5995 and Members of the Department
Quarter course (fall term). F., 9–12.
Introduction to advanced scientific visualization techniques using leading 3D software packages Maya and Molecular Maya. Focus will be placed on adapting existing 3D modeling/animation tools for purposes of visualizing biological processes.

*BCMP 303qc. Molecular Movies: Advanced 3D Visualization with Maya
Catalog Number: 61072 Enrollment: Limited to 18.
David Lopes Cardozo (Medical School) 5995
Quarter course (spring term). F., 9–12.
Explore Maya’s vast visualization toolset. Advanced techniques in each of the phases of the 3D production pipeline will be presented including dynamics systems like Hair, nCloth, nParticles and PaintFx. Introduction to Maya’s Embedded Language (MEL).
Prerequisite: Molecular Movies: Introduction to 3D Visualization with Maya required.

*BCMP 307qc. Approaches to Drug Action, Discovery, and Design
Catalog Number: 52371 Enrollment: May be limited.
Nathanael Gray (Medical School) 5730, and members of the Department
Quarter course (spring term). Tu., Th., 3:30–5.
Application of molecular, systems, and structural biology, genetics, genomics, enzymology, and chemistry to development of new therapies. Examples drawn from diseases including cancer and AIDS. Students write and present proposals for discovery of new therapeutics.

*BCMP 308qc. Cell Fate Decisions in Development and Disease
Catalog Number: 21552 Enrollment: Limited to 12.
Alan B. Cantor (Medical School) 5150
Quarter course (fall term). W., 1:30 - 3:30.
This quarter course will offer students an in-depth examination of current knowledge regarding mechanisms of cell fate decisions. In addition, it will examine these processes in the context of developmental cell plasticity, cellular reprogramming, and cancer. This will primarily be a literature-based course, with examination and discussion of key studies in the field. Concepts involving epigenetics, chromatin remodeling, the instructive roles of transcription factors, transcription factor networks, transcription factor cross-antagonism, feedback loops, multilineage priming, non-coding RNAs, lineage identity maintenance, mitotic bookmarking, lateral inhibition, and cell signaling will be explored. These ideas will be examined in the context of blood, breast, lung, and gastrointestinal tract development.

*BCMP 309qc. Principles of Drug Action in Man
Catalog Number: 63265
Timothy J. Mitchison (Medical School) 3713
Quarter course (spring term). Tu., Th., 3:30–5.
This course pairs with BCMP 307qc. Approaches to Drug Action, Discovery, and Design.

*BCMP 311qc. Unmet Medical Needs and Translational Solutions - (New Course)
Catalog Number: 41566
Jagesh V. Shah (Medical School) 5248 and members of the Medical School faculty
Quarter course (fall term). M. through F., 9–5.
The central goal of modern biomedical research is to understand the cause of human disease and to use this knowledge to develop approaches that lessen human suffering. The path from identifying an unmet medical need through the development of interventions that impact disease is a complex process demanding the best of medicine and science, strong project management, significant financial support, and persistence. In this course, students will learn to evaluate how unmet medical needs can be "translated" into new clinical practices. The course will feature assessment of unmet medical needs, case studies of successes and failures in translation, seminars from translational medicine experts, and workshops that engage students in substantive and intense discussions on current topics. Lecturers will include innovators who have successfully led the development of therapeutic interventions, leaders in basic science who have helped uncover the underlying causes of disease and investigators who have led clinical trials that lead to the approval of new interventions.
Note: This course will meet Mondays through Fridays, from Monday, July 7, 2014 to Friday, July 18, 2014.

Cell Biology

Primarily for Graduates

Cell Biology 201. Molecular Biology of the Cell
Catalog Number: 1044
Marcia C. Haigis (Medical School)
Half course (spring term). M., W., 10:30-12, and sections F., at 10:30-12. EXAM GROUP: 5
Molecular basis of cellular compartmentalization, protein trafficking, cytoskeleton dynamics, mitosis, cell locomotion, cell cycle regulation, signal transduction, cell-cell interaction, cell death, and cellular/biochemical basis of diseases.
Note: Methodological focus on current approaches in cell biology including quantitative tools. Emphasis on experimental design. Offered jointly with the Medical School as CB 713.0.
Prerequisite: Basic knowledge in biochemistry, genetics and cell biology.

Cell Biology 207. Developmental Biology: Molecular Mechanisms of Vertebrate Development
Catalog Number: 2044 Enrollment: Limited to 25.
Andrew B. Lassar (Medical School), John G. Flanagan (Medical School), Wolfram Goessling (Medical School), Jordan A. Kreidberg (Medical School), Sean Megason (Medical School), Trista Elizabeth North (Medical School), Ramesh Shivdasani (Medical School), Jessica Whited (Medical School), and Malcolm Whitman (Dental School)
Half course (spring term). M., Th., 2–4. EXAM GROUP: 18
Analyzes the developmental programs of frog, chick, zebrafish, and mouse embryos, emphasizing experimental strategies for understanding the responsible molecular mechanisms that pattern the vertebrate embryo. Morphogenesis, organogenesis, stem cells and regeneration will also be discussed.
Note: Offered jointly with the Medical School as CB 710.0. Includes lectures and conference sessions in which original literature is discussed in depth. Short research proposals are required in lieu of exams.

[Cell Biology 211. Molecular and Systems Level Cancer Cell Biology]
Catalog Number: 5771
Piotr Sicinski (Medical School), Jarrod Marto (Medical School), and Marc Vidal (Medical School)
Half course (spring term). M., W., 1–2:30.
Examines the molecular basis of cancer formation including alterations in signal transduction pathways, cell cycle machinery, cell metabolism and apoptosis. Describes novel systems biology proteomic approaches to study cancer cell interactomes.
Note: Expected to be given in 2015–16. Expected to be given in 2015-2016. Given alternate years with Cell Biology 212. Offered jointly with the Medical School as CB 704.0.
Prerequisite: General knowledge of biochemistry, molecular genetics, and cell biology.

Cell Biology 212. Biology of the Cancer Cell
Catalog Number: 4169
David A. Frank (Medical School) and Jean J. Zhao (Medical School)
Half course (spring term). M., W., 12:30-2:00. EXAM GROUP: 7
This semester long course takes a molecular approach to examine the basis of human cancer. The main concepts that we will cover include: tumor suppressor genes and oncogenes, signal transduction, DNA damage and repair, angiogenesis, metastasis and invasion, and apoptosis. Lectures will be delivered by experts in the various fields of Cancer Biology research to provide an integrated perspective on past, current and future approaches in Cancer Biology Research.
Note: Given alternate years with Cell Biology 211.
Prerequisite: Advanced biochemistry, molecular genetics, and cell biology.

Cell Biology 225. Hormonally Active Pollutants and Human Disease
Catalog Number: 94802
Joan V. Ruderman (Medical School)
Half course (spring term). Th., 4:30–6:30. EXAM GROUP: 6
Surprising number of environmental pollutants can mimic or interfere with developmental and physiological effects of hormones. This course examines landmark discoveries and legislation, and emphasizes current work in this emerging area.
Note: Intended for interested students from all concentrations.

Cell Biology 226. Concepts in Development, Self-Renewal, and Repair
Catalog Number: 8747 Enrollment: Limited to 12.
Iain A. Drummond (Medical School) and Andrew Stephen Brack (Medical School)
Half course (fall term). F., 2–5. EXAM GROUP: 7
Explores developmental mechanisms through the life cycle, contrasting pluripotency and cell fate restriction in embryos and adult tissues. In depth analysis of in vivo approaches, with emphasis on adult stem cells, tissue repair and self-renewal.
Note: Offered jointly with the Medical School as CB 721.0. For more information visit: Massachusetts General Hospital and select CB 226.
Prerequisite: Upper division cell biology or equivalent.

Graduate Courses of Reading and Research

*Cell Biology 300. Advanced Topics in Cell, Molecular, and Developmental Biology
Catalog Number: 5825
David Lopes Cardozo (Medical School) 5995
A series of reading and discussion seminars, each running for a half term (seven weeks). Different topics are covered each term.
Note: Two seminars, which can be taken in different terms, are required for credit. Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 617-432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*Cell Biology 305. Bone Cells Differentiation, Function and Signaling
Catalog Number: 60379
Roland Elie Baron 6397

*Cell Biology 306. Chromatin Dynamics in metabolism and DNA repair
Catalog Number: 75486
Raul Mostoslavsky (Medical School) 6402

*Cell Biology 307. Cell-cell signaling in neural development and regeneration
Catalog Number: 1911
John G. Flanagan (Medical School) 3149

*Cell Biology 310. Mechanisms of Vertebrate Hedgehog Signaling
Catalog Number: 9189
Adrian Salic (Medical School) 5351

*Cell Biology 311. Cardiovascular Signal Transduction
Catalog Number: 9196
Thomas Michel (Medical School) 4392

*Cell Biology 312. Molecular Mechanisms of Transcriptional Control
Catalog Number: 8538
Anders Michael Naar (Medical School) 4328

*Cell Biology 313. Systems Biology of Mammalian Signal Transduction
Catalog Number: 23964
Peter K. Sorger (Medical School) 5544

*Cell Biology 314. Molecular Biology of Extracellular Matrix
Catalog Number: 5077
Bjørn R. Olsen 1164

*Cell Biology 316. Mechanism and Function of Intracellular Protein Turnover
Catalog Number: 1017
Alfred L. Goldberg (Medical School) 2827

*Cell Biology 317. Mechanisms of Programmed Cell Death
Catalog Number: 2270
Junying Yuan (Medical School) 2105

*Cell Biology 318. Molecular Biology of Cell Growth Regulation and Transformation
Catalog Number: 3355
John Blenis (Medical School) 2612

*Cell Biology 319 (formerly Pathology 368). Signaling Pathways in Cancer Cell Biology
Catalog Number: 71626
Alex Toker (Medical School) 4971

*Cell Biology 321. Neuronal Pathfinding and Synaptogenesis
Catalog Number: 4841
David L. Van Vactor (Medical School) 2089

*Cell Biology 325. Molecular and Cellular Regulators of Cancer Progression
Catalog Number: 27821
Sandra McAllister (Medical School) 3226

*Cell Biology 326. Signal Transduction During Early Development
Catalog Number: 1872
Malcolm Whitman (Dental School) 3267

*Cell Biology 328. Single-molecule biology and visualization of cellular dynamics
Catalog Number: 0438
Tomas Kirchhausen (Medical School) 1155

*Cell Biology 329. The Ubiquitin-Proteasome Pathway
Catalog Number: 6826
Daniel Finley (Medical School) 2313

*Cell Biology 332. Mass Spectrometry and Proteomics
Catalog Number: 1568
Instructor to be determined

*Cell Biology 333. Electron Microscopic Structure Determination
Catalog Number: 9254
Thomas Walz (Medical School) 3778

*Cell Biology 336. Signal Transduction in Normal and Transformed Cells
Catalog Number: 6833
Joan S. Brugge (Medical School) 1486

*Cell Biology 339. Cell Morphogenesis and Regulation
Catalog Number: 3898
Marc W. Kirschner (Medical School) 1078

*Cell Biology 343. Mechanisms of Mammalian Cell Differentiation and Gene Expression
Catalog Number: 0202
Bruce M. Spiegelman (Medical School) 7733

*Cell Biology 344. Molecular Mechanism of Signal Transduction
Catalog Number: 6093
Xi He (Medical School) 2004

*Cell Biology 345. Protein Transport Across the Endoplasmic Reticulum Membrane
Catalog Number: 6793
Tom Rapoport (Medical School) 1815

*Cell Biology 346. Molecular Basis of Human Disease
Catalog Number: 1591
Andrius Kazlauskas (Medical School) 2088

*Cell Biology 347. Cellular and Molecular Aspects of Insulin Action
Catalog Number: 1494
C. Ronald Kahn (Medical School) 2019

*Cell Biology 348. Transcriptional regulation and epigenetics in breast and prostate cancer
Catalog Number: 87887
Myles A. Brown (Medical School) 1789

*Cell Biology 349. Gene Silencing and Chromosome Structure
Catalog Number: 8765
Danesh Moazed (Medical School) 4254

*Cell Biology 351. Cardiovascular Stem Cells in Development and Disease
Catalog Number: 7604
Kenneth R. Chien 5667

*Cell Biology 354. Basic and Applied Mechanisms of Intracellular Transport
Catalog Number: 7605
Victor Wee Hsu (Medical School) 2606

*Cell Biology 356. Cell Growth Regulation, Telomere Maintenance, Cancer and Alzheimer’s Disease
Catalog Number: 3718
Kun Ping Lu (Medical School) 2607

*Cell Biology 358. Mechanisms of Tumor Metastasis
Catalog Number: 0606
Bruce R. Zetter (Medical School) 7737

*Cell Biology 359. Intracellular Signaling Pathways in the Regulation of Cell Growth and Differentiation
Catalog Number: 0335
David A. Frank (Medical School) 3276

*Cell Biology 360. Genetic Control of Apoptosis in Drosophila
Catalog Number: 6046
Kristin White (Medical School) 3955

*Cell Biology 365. Mechanism and biology of ubiquitin-like protein conjugation cascades
Catalog Number: 96188
J. Wade Harper (Medical School) 4957

*Cell Biology 366. Mitochondria in Aging and Metabolism
Catalog Number: 44666
Marcia C. Haigis (Medical School) 5734

*Cell Biology 370. Mitotic Kinases, Chromatin and Chromosome Segregation
Catalog Number: 0661
Jonathan M. G. Higgins (Medical School) 5543

*Cell Biology 371. Nutrient Sensing and Metabolic Control
Catalog Number: 5804
Pere B. Puigserver (Medical School) 5735

*Cell Biology 372. Cytoskeletal Dynamics
Catalog Number: 5032
Timothy J. Mitchison (Medical School) 3713

*Cell Biology 373. Molecular Genetics of Cell Interaction in Development
Catalog Number: 8133
Spyros Artavanis-Tsakonas (Medical School) 2609

*Cell Biology 374. Cell-extracellular matrix interaction in brain development and malformation
Catalog Number: 35175
Xianhua Piao (Medical School) 7046

*Cell Biology 375. Cancer Genetics and DNA
Catalog Number: 26444
David Marc Weinstock (Medical School) 6929

*Cell Biology 376. Chemical Approaches to Cell Division and Cancer
Catalog Number: 7680
Randy King (Medical School) 3941

*Cell Biology 377. Islet cell signaling mechanisms, Stem cells, iPS Cells in diabetes
Catalog Number: 7966
Rohit N. Kulkarni (Medical School) 5152

*Cell Biology 378. Bacterial Toxin Entry and Immunoglobulin Transport in Mucosal Epithelial Cells
Catalog Number: 7656
Wayne I. Lencer (Medical School) 5153

*Cell Biology 379. BMP Signaling in Organogenesis
Catalog Number: 2894
Vicki Rosen (Dental School) 4790

*Cell Biology 380. Cytoskeletal Mechanics of Blood Platelet Production
Catalog Number: 9706
Joseph E. Italiano (Medical School) 5392

*Cell Biology 381. Molecular Mechanism of Microtubule-based Motility
Catalog Number: 8578
Samara Louise Reck-Peterson (Medical School) 6165

*Cell Biology 382. Regulation of Rho GTPases by synaptopodin
Catalog Number: 16967
Peter Hermann Mundel (Medical School) 7040

*Cell Biology 383. Molecular Biology of Instinctive Animal Behavior
Catalog Number: 8119
Stephen Daniel Liberles (Medical School) 6159

*Cell Biology 385. Epigenetic mechanisms and genomic integrity
Catalog Number: 72714
Mohammad Motamedi (Medical School) 7039

*Cell Biology 386. Systemic metabolism and cancer
Catalog Number: 41321
Nada Y. Kalaany (Medical School) 7026

*Cell Biology 387. Calcium signaling in health and disease
Catalog Number: 81727
Anna Greka (Medical School) 7021

*Cell Biology 389. Modeling ovarian cancer pathogenesis and early detection
Catalog Number: 97721
Ronny I. Drapkin (Medical School) 5912

*Cell Biology 390. Membrane: cytoskeleton interface in morphogenesis and tumorigenesis/metastasis
Catalog Number: 31092
Andrea I. McClatchey (Medical School) 2204

*Cell Biology 399. Nanocourses
Catalog Number: 0087
David Lopes Cardozo (Medical School) 5995 and Spyros Artavanis-Tsakonas (Medical School) 2609

Quarter Courses for Graduate Students Only

*Cell Biology 300qc. Advanced Topics in Cell, Molecular, and Developmental Biology
Catalog Number: 17665
David Lopes Cardozo (Medical School) 5995
A series of reading and discussion seminars, each running for a half term (7 weeks).
Note: Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 617-432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*Cell Biology 301qc. The Epidemiology and Molecular Pathology of Cancer
Catalog Number: 24657
Instructor to be determined
Quarter course (spring term). M. through F., 9:30–5.
This January course will provide students with an in-depth introduction to the epidemiology and molecular pathology of cancer. We will explore multiple types of cancer, including breast, colon, lung, prostate and brain, through a series of lectures and hands-on practice tutorials. These tutorials will include training in molecular pathology techniques, state of the art image analysis of human biomarkers, tissue processing, immunohistochemistry, and tumor histology. In addition, the epidemiology, genetics and relevant signal transduction pathways of cancer will be highlighted.
Note: This is an intensive January course. Curriculum Fellow: Megan Mittelstadt, 617-432-7498.

*Cell Biology 302qc. Advanced Experimental Design for Biologists
Catalog Number: 91286 Enrollment: Limited to 24.
Randy King (Medical School) 3941 and David Jonathan Glass (Medical School)
Quarter course (spring term). M., W., 4–6.
Theory and practice of experimental design. Build on principles from experimental design boot camp. Conducted in workshop setting to apply those principles to current student projects. Emphasis placed on interpretation and strategic project planning.

*Cell Biology 304qc. Introduction to Human Gross Anatomy
Catalog Number: 61023 Enrollment: Limited to 10.
David Lopes Cardozo (Medical School) 5995, Gerald Greenhouse (Medical School), Everett Anderson (Medical School), Mohini Lutchman (Medical School)
Quarter course (spring term). M., W., F., 12–7, and some 12-5.
Lectures, laboratory dissections, and prosections to explore the gross structure and function of the human body. Provide a foundation to acquire practical skills in recognizing, dissecting, and differentiating key anatomical structures.
Note: Open to graduate students only.

*Cell Biology 305qc. Intracellular transport
Catalog Number: 61228
Victor Hsu (Medical School) and invited faculty
Quarter course (fall term). Tu., 3–5.
This course will provide a practical guide to understanding the role of intracellular transport in physiology and disease settings. Basic mechanisms and also interdisciplinary areas that involve this fundamental cellular process will be selected for discussion.
Note: Offered in alternate years.

*Cell Biology 306qc. Teaching 100: The Theory and Science of Teaching
Catalog Number: 62351 Enrollment: Limited to 15.
Johanna Gutlerner 7590 and David L. Van Vactor (Medical School) 2089
Quarter course (fall term). Th., 1–3:30.
For many graduate students, teaching will be part of their career, whether as mentoring, formal classroom teaching, or outreach. In addition, the theory and research evidence accumulating in the disciplines of cognitive psychology, neuroscience, and from STEM classrooms, has turned the question of, ’How do we best teach science?’ into its own scientific discipline. The Theory and Science of Teaching focuses on understanding why certain teaching methods are effective by examining the scientific research and theoretical frameworks that support these methods. We will read and discuss foundational educational and cognitive psychology texts and primary literature, and then develop an annotated lesson plan that allows us to put these ideas into practice.
Note: The course has been designed as a companion to Genetics 302qc: Teaching 101, but neither course is a prerequisite of the other.

*Cell Biology 307qc. Molecular Aspects of Chromatin Dynamics
Catalog Number: 91774 Enrollment: Limited to 25.
Raul Mostoslavsky 6402, Danesh Moazed (Medical School), Johnathan Whetstine (Medical School), and Lee Zou (Medical School), and members of the Department
Quarter course (spring term). Hours to be arranged.
Discuss chromatin dynamics in modulating cellular processes. Cover molecular mechanisms that regulate chromatin dynamics. How chromatin itself modulates biological processes, including mechanisms of inheritance. Discuss DNA methylation, histone modifications, nucleosome dynamics and novel epigenetic modulators.

*Cell Biology 308qc. Introduction to Histology
Catalog Number: 38084 Enrollment: Limited to 11.
Adrian Salic (Medical School), Gerald Greenhouse (Medical School) and Stephen Daniel Liberles (Medical School)
Quarter course (spring term). M., W., F., 1-5.
The study of structure and how structure relates to function, in cells and tissues.

*Cell Biology 309qc. Advanced Topics in Cell Biology
Catalog Number: 14797
David L. Van Vactor (Medical School) 2089 and members of the Medical School
Quarter course (spring term). Tu., 6–7:30.
Dinner Seminar Theme: Controlling Cellular Behavior and Metabolism through Cell Interaction and Signaling. Review articles assigned each week to prepare students for discussion.

*Cell Biology 310qc. Current Topics in Cancer Biology Research
Catalog Number: 60742
Charles D. Stiles (Medical School) 4828
Quarter course (spring term). M., W., F., 2:30-4.
This course is designed for mid- to upper-year graduate students that are interested in Current Topics in Cancer Biology research. Leading and cutting edge technologies in Cancer Biology Research are explored in-depth using recent papers of high profile in a round-table discussion format. Topics include: Cancer Cell Signaling, Metastasis and EMT, Cancer Genomics, Cancer and microRNAs and Cancer Stem Cells.

*Cell Biology 311qc. Recent Advances in Cell Biology
Catalog Number: 86396 Enrollment: Open to first-year and second-year BBS students.
David L. Van Vactor (Medical School) 2089 and Wade Harper (Medical School) 4957
Quarter course (spring term). .
Provides a comprehensive overview on the most recent advances in cell biology, covering hands-on experimental sessions including, electron microscopy, live cell imaging, single molecule imaging, 3D cultures, quantitative proteomics, protein interaction mapping, and more.
Note: Meeting dates and times: Monday, January 6 to Wednesday, January 22, 2014; 9-6 pm. Not repeatable for credit.

Developmental and Regenerative Biology

Graduate Course

*DRB 310. Blood Stem Cell Development and Regeneration
Catalog Number: 35575
Trista Elizabeth North (Medical School) 6515

*DRB 311. Cardiovascular Stem Cell Biology
Catalog Number: 50682
Caroline Erter Burns (Medical School) 6516

*DRB 312. Epigenetic Modifications and Cellular Identity
Catalog Number: 65789
Alexander Meissner 6702

*DRB 313. Liver Development, Regeneration and Carcinogenesis
Catalog Number: 14267
Wolfram Goessling (Medical School) 6563

*DRB 314. Investigation of the molecular mechanisms governing development and reprogramming of neuronal subtypes in the mammalian cerebral cortex.
Catalog Number: 80896
Paola Arlotta 6703

*DRB 315. Environmental Signaling, Plasticity and Fate Specification during Development
Catalog Number: 29374
Susan Mango 6386

*DRB 316. Stem Cells and Organ Size Control
Catalog Number: 96003
Fernando D. Camargo 6401

*DRB 317. Stem cells, Cancer, and Hematological Disorders
Catalog Number: 44481
Catherine T. Yan (Medical School) 6517

*DRB 318. Adult hippocampal neurogenesis, cognition and affective behaviors
Catalog Number: 18357
Amar Sahay (Medical School) 7195

*DRB 319. Adult mammalian regeneration
Catalog Number: 45223
Qiao Zhou 6578

*DRB 320. Lung Regeneration and Lung Disease
Catalog Number: 42137
Jayaraj Rajagopal (Medical School) 6762

*DRB 321. Stem Cells and Neurodegenerative Disease
Catalog Number: 30604
Lee L. Rubin 6061

*DRB 322. Regulation of tissue stem cells
Catalog Number: 80827
David T. Breault (Medical School) 2595

*DRB 324. Adult skeletal muscle stem cell regulation
Catalog Number: 88077
Andrew Stephen Brack (Medical School) 7008

*DRB 325 (formerly Pathology 371). Biology and Function of Tissue-Specific Stem Cells
Catalog Number: 85039
Amy J. Wagers 5212

*DRB 326 (formerly Pathology 385). Epigenetic Regulation by Large Non-coding RNA
Catalog Number: 14839
John L. Rinn 6229

*DRB 331. Critical Analysis and Experimental Approaches in Developmental Biology
Catalog Number: 22543 Enrollment: Limited to 16.
Paola Arlotta 6703 and members of the Department
Half course (spring term). M. through Sa., 12–6.
This course will provide a survey of major topics and contemporary research in developmental and regenerative biology. Students will rotate in the laboratories of DRB faculty across the Harvard campuses and affiliated hospitals. Students engage with faculty and gain hands on experience in a variety of model systems, techniques and research areas. Each day of the course will consist of a lecture followed by hands-on laboratory activities and interactive discussions. Students will be required to complete the lab experience and the following assignments: lead two chalk-talk format paper presentations, and write one 5-6 page research proposal.

Quarter Course for Graduate Students Only

*DRB 330qc. Experimental Approaches to Developmental Biology
Catalog Number: 6590 Enrollment: Limited to 16.
Paola Arlotta 6703, and members of the Department
Quarter course (spring term). M. through Sa., 12–6, January 6th-January 17th, 2014.
This laboratory course is designed to provide a survey of major topics and contemporary research in developmental and regenerative biology. Students will rotate in the laboratories of DRB faculty across the Harvard campuses and affiliated hospitals. Students engage with faculty and gain hands on experience in a variety of model systems, experimental techniques and research areas. Each day of the course will consist of a lecture followed by hands-on laboratory activities and interactive discussions.
Note: Open to first-year and second-year BBS students; Not repeatable for credit. January course.

Genetics

Primarily for Graduates

Genetics 201. Principles of Genetics
Catalog Number: 4225
Fred Winston (Medical School), Thomas G. Bernhardt (Medical School), Maxwell G. Heiman (Medical School), Mitzi I. Kuroda (Medical School), and Steven A. McCarroll (Medical School)
Half course (fall term). M., W., F., 9-10:30. EXAM GROUP: 10
An in-depth survey of genetics, beginning with basic principles and extending to modern approaches and special topics. We will draw on examples from various systems, including yeast, Drosophila, C. elegans, mouse, human and bacteria.
Note: Intended for first-year graduate students. Offered jointly with the Medical School as GN 701.0.

[Genetics 202. Human Genetics]
Catalog Number: 8064 Enrollment: Minimum of 8 and maximum of 30 students.
Matthew L. Warman (Medical School) and members of the Department
Half course (spring term). M., 12:30–4.
This course examines genetic principles and experimental approaches for addressing fundamental questions about human variation, history, health, and disease. Each session is comprised of a lecture followed by a class discussion.
Note: Expected to be given in 2015–16.
Prerequisite: Genetics 201 (or permission of the instructor) and basic knowledge of probability and statistics. Familiarity with bioinformatics and computational tools will be useful, but tutorial assistance will be provided where necessary.

Genetics 216. Advanced Topics in Gene Expression
Catalog Number: 2244
Robert E. Kingston (Medical School) and Fred Winston (Medical School)
Half course (spring term). Tu., 1–4. EXAM GROUP: 1
Covers both biochemical and genetic studies in regulatory mechanisms. Small number of topics discussed in depth, using the primary literature. Topics range from prokaryotic transcription to eukaryotic development.
Note: Offered jointly with the Medical School as GN 703.0.
Prerequisite: BCMP 200 and Genetics 201.

Genetics 219. Inheritance and Weird Stuff
Catalog Number: 14189
Chao-Ting Wu (Medical School) and Kami Ahmad (Medical School)
Half course (spring term). Tu., 11-2.
Focus on patterns of inheritance, including those that were once considered extraordinary but are now recognized as paradigms spanning fungi to humans. Expectations: questions, ideas, conversation during class. No tests, problem sets, or papers.
Prerequisite: Primarily for first-year graduate students, but is open to medical students and advanced undergraduates. A basic understanding of genetics recommended.

Genetics 220. Molecular Biology and Genetics in Modern Medicine
Catalog Number: 4660
Kiran Musunuru
Half course (fall term). F., 8:30-12:30, Tu., 2-5. EXAM GROUP: 10
This course will provide a firm foundation for understanding the relationship between molecular biology, developmental biology, genetics, genomics, bioinformatics, and medicine. The goal is to develop explicit connections between basic research, medical understanding, and the perspective of patients. During the course the principles of human genetics will be reviewed. Students will become familiar with the translation of clinical understanding into analysis at the level of the gene, chromosome and molecule, the concepts and techniques of molecular biology and genomics, and the strategies and methods of genetic analysis, including an introduction to bioinformatics. The course will extend beyond basic principles to current research activity in human genetics.
Note: Offered jointly with the Medical School as HT 160.

Genetics 228. Genetics in Medicine - From Bench to Bedside
Catalog Number: 9840
Susan A. Slaugenhaupt (Medical School) and Christopher Holmes Newton-Cheh (Medical School)
Half course (spring term). F., 2–5. EXAM GROUP: 18
Focus on translational medicine: the application of basic genetic discoveries to human disease. Will discuss specific genetic disorders and the approaches currently used to speed the transfer of knowledge from the laboratory to the clinic.
Note: Course will include patient presentations and lectures by investigators known for their work in a specific disease area. Course will be held at MGH (transportation provided to MGH). Offered jointly with the Medical School as GN 711.0. For more information visit the Massachusetts General Hospital.
Prerequisite: Genetics 201 or equivalent.

Graduate Courses of Reading and Research

*Genetics 300. Advanced Topics in Genetics
Catalog Number: 1037
David Lopes Cardozo (Medical School) 5995
A series of reading and discussion seminars, each running for a half term (seven weeks). Different topics are covered each term.
Note: Two seminars, which can be taken in different terms, are required for credit. Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*Genetics 303. Molecular Biology of Pathogenesis
Catalog Number: 1972
Frederick Ausubel (Medical School) 4639

*Genetics 304. Molecular Genetics Basis of Human Disease, Particularly Cardiovascular Pathogenesis
Catalog Number: 0693
Christine E. Seidman (Medical School) 3013

*Genetics 305. Centrosomes, Cilia, Cysts and Diseases
Catalog Number: 9027
Jing Zhou (Medical School) 3779

*Genetics 306. Inherited Human Disorders
Catalog Number: 7324
Jonathan G. Seidman (Medical School) 7529

*Genetics 308. Molecular Biology of Signal Transduction
Catalog Number: 5616
Brian Seed (Medical School) 7619

*Genetics 309. Gene Expression in Yeast
Catalog Number: 3763
Fred Winston (Medical School) 7877

*Genetics 310. Molecular Genetics of Neural Development and Gene Therapy to Prevent Blindness
Catalog Number: 6324
Constance L. Cepko (Medical School) 1150

*Genetics 311. Molecular Mechanisms of Transcription Regulation in Mammals
Catalog Number: 7310
Robert E. Kingston (Medical School) 1153

*Genetics 312. Molecular Genetics of Development
Catalog Number: 8363
Gary B. Ruvkun (Medical School) 1366

*Genetics 313. Genomic Approaches to Human Disease Genetics
Catalog Number: 6059
David M. Altshuler (Medical School) 4307

*Genetics 314. Structure and Activities of Ribozymes
Catalog Number: 7244
Jack Szostak (Medical School) 7096

*Genetics 315. Molecular Genetics of Inherited Disorders
Catalog Number: 3362
James Gusella (Medical School) 1152

*Genetics 316. Transcription Factors and DNA Regulatory Elements
Catalog Number: 2247
Martha L. Bulyk (Medical School) 4259

*Genetics 317. Signaling Networks in Development and Disease
Catalog Number: 2271
Jordan A. Kreidberg (Medical School) 2080

*Genetics 318. Genome Structure
Catalog Number: 5012
George M. Church (Medical School) 1608

*Genetics 320. Genetics of Common Human Disease
Catalog Number: 39071
Mark Joseph Daly (Medical School) 6519

*Genetics 321. Genetic Analysis of Growth and Homeostasis
Catalog Number: 6501
Norbert Perrimon (Medical School) 1679

*Genetics 322. Vertebrate Pattern Formation
Catalog Number: 0436
Clifford J. Tabin (Medical School) 2430

*Genetics 323. Molecular Biology of V(D)J Recombination
Catalog Number: 6950
Marjorie A. Oettinger (Medical School) 3172

*Genetics 325. Human Genetics, Genomics and Complex Traits
Catalog Number: 8275
Joel N. Hirschhorn (Medical School) 4321

*Genetics 326. Human Molecular and Cancer Genetics
Catalog Number: 2900
David J. Kwiatkowski (Medical School) 3770

*Genetics 327. Systems Biology of Mammalian Cell Fate Decisions
Catalog Number: 69285
Suzanne Gaudet (Medical School) 6183

*Genetics 328. Lymphocyte Differentiation, Recombination, DNA Repair, Cancer
Catalog Number: 2702
Frederick W. Alt (Medical School) 3146

*Genetics 329. Genetic Analysis of Synaptic Transmission
Catalog Number: 9734
Joshua M. Kaplan (Medical School) 3522

*Genetics 331. Developmental Oncobiology and Cancer Stem Cells
Catalog Number: 17763
Zhe Li (Medical School) 7193

*Genetics 332. Combining genetic and biochemical approaches to elucidate mechanisms underlying cancer
Catalog Number: 2975
Karen M. Cichowski (Medical School) 3932

*Genetics 333. Computational biology of transcriptional and epigenetic regulation
Catalog Number: 96777
Xiaole Shirley Liu (Public Health) 4911

*Genetics 334. Genomics and the Genetics of Human Disease
Catalog Number: 5144
Raju Kucherlapati (Medical School) 4324

*Genetics 335. Genetics, epigenetics, gene regulation, evolution, disease
Catalog Number: 4982
Chao-Ting Wu (Medical School) 3535

*Genetics 336. Developmental Biology of Hematopoiesis
Catalog Number: 7165
Leonard I. Zon (Medical School) 1137

*Genetics 337. Human Molecular Genetics
Catalog Number: 7194
Stuart H. Orkin (Medical School) 7402

*Genetics 341. Development and Homeostasis of the Skeleton
Catalog Number: 8874
Matthew L. Warman (Medical School) 5875

*Genetics 342. Genetic Analysis of Zebrafish Kidney Organogenesis
Catalog Number: 4498
Iain A. Drummond (Medical School) 5350

*Genetics 343. Zebrafish cardiovascular development and regeneration
Catalog Number: 76107
Charles Geoffrey Burns (Medical School) 7433

*Genetics 344. Computational Genomics
Catalog Number: 2125
Peter J. Park (Medical School) 5917

*Genetics 347. Ras signaling and colon cancer
Catalog Number: 72917
Kevin M. Haigis (Medical School) 5913

*Genetics 350. Genetic Regulation of Organogenesis and Organ Regeneration
Catalog Number: 4974
Richard L. Maas (Medical School) 3703

*Genetics 352. Cardiovascular Development and Disease, Muscle Biology
Catalog Number: 58035
Da-Zhi Wang (Medical School) 3228

*Genetics 353. Genetics of Human Disease
Catalog Number: 6608
Susan A. Slaugenhaupt (Medical School) 5483

*Genetics 354. Integrative genomics of cancer and autism
Catalog Number: 53387
Isaac S. Kohane (Medical School) 4531

*Genetics 355. Molecular Genetics of Human Neuromuscular Diseases
Catalog Number: 9253
Alan H. Beggs (Medical School) 1422

*Genetics 356. Research in Molecular Cytogenetics
Catalog Number: 21395
Cynthia C. Morton (Medical School) 2194

*Genetics 357. Lung Stem Cell Biology and Cancer
Catalog Number: 9494
Carla Kim (Medical School) 5742

*Genetics 358. Developmental Neurobiology and Genetics
Catalog Number: 8297
Susan M. Dymecki (Medical School) 1736

*Genetics 359. Cancer and Development, Thrombopoiesis, Intestinal Development
Catalog Number: 9880
Ramesh Shivdasani (Medical School) 4538

*Genetics 360. Microtubule Associated RNAs During Mitosis
Catalog Number: 5677
Michael Demian Blower (Medical School) 5733

*Genetics 361. Mechanism of X-inactivation in Mammals
Catalog Number: 9152
Jeannie T. Lee (Medical School) 2129

*Genetics 362. Molecular Biology and Genetics of Cancer
Catalog Number: 9382
David Morse Livingston (Medical School) 4872

*Genetics 366. Molecular Genetic Approaches to Human Disease Mechanisms
Catalog Number: 8153
Marcy E. MacDonald (Medical School) 2635

*Genetics 368. Molecular Genetics of Aging and Neurodegenerative Disorders
Catalog Number: 50867
Bruce Yankner (Medical School) 1557

*Genetics 369. Molecular Mechanisms of Plant Signal Transduction
Catalog Number: 3010
Jen Sheen (Medical School) 3892

*Genetics 370. Molecular Basis of Breast Cancer Initiation and Progression
Catalog Number: 4519
Kornelia Polyak (Medical School) 3898

*Genetics 371. Functional Genomics and Proteomics
Catalog Number: 2190
Marc Vidal (Medical School) 3914

*Genetics 372. Molecular Mechanisms of Aging and Age Related Diseases
Catalog Number: 65974
David A. Sinclair (Medical School) 2610

*Genetics 373. Kidney Disease, Genetics, Cytoskeleton
Catalog Number: 3875
Martin R. Pollak (Medical School) 4329

*Genetics 374. Mechanisms underlying accurate meiotic chromosome segregation
Catalog Number: 4419
Monica P. Colaiácovo (Medical School) 4949

*Genetics 376. Cell Cycle Control and Genomic Integrity
Catalog Number: 3788
Stephen J. Elledge (Medical School) 4954

*Genetics 377. Molecular Genetics of Chromosome Organization and Gene Expression
Catalog Number: 0811
Mitzi I. Kuroda (Medical School) 4959

*Genetics 378. Aging, Stress Defenses, and Developmental Gene Regulation in C. elegans
Catalog Number: 14452
T. Keith Blackwell (Medical School) 1826

*Genetics 379. Applying Population Genetics to Find Disease Genes
Catalog Number: 1677
Instructor to be determined

*Genetics 380. Molecular Approaches to Metabolism and Energy Balance
Catalog Number: 4688
Evan David Rosen (Medical School) 4966

*Genetics 382. Muscle Stem Cell Commitment and Differentiation
Catalog Number: 2626
Emanuela Gussoni (Medical School) 5155

*Genetics 385. Cell Cycle Proteins in Development and Cancer
Catalog Number: 81081
Piotr Sicinski (Medical School) 2245

*Genetics 387. Stem Cells and Developmental Biology
Catalog Number: 4080
Chad A. Cowan 6099

*Genetics 388. Genetics of Neuronal Morphogenesis and Connectivity in C. Elegans
Catalog Number: 63445
Maxwell G. Heiman (Medical School) 3225

*Genetics 389. Epigenomics of Allele-Specific Expression
Catalog Number: 29559
Alexander Gimelbrant (Medical School) 6521

*Genetics 391. Human Genome Structural and Regulatory Variation
Catalog Number: 51043
Steven A. McCarroll (Medical School) 6557

*Genetics 392 (formerly *Pathology 318). Self-Renewal and Cancer
Catalog Number: 10448
David M. Langenau (Medical School) 6459

*Genetics 393. Genetic basis of skeletal development and evolution
Catalog Number: 71384
Matthew Harris (Medical School) 6954

*Genetics 394. How transcriptional networks rewire neuronal circuits
Catalog Number: 42703
Jesse M. Gray (Medical School) 3469

*Genetics 395. Global studies of transcription elongation
Catalog Number: 72253
Lee Stirling Churchman (Medical School) 3222

*Genetics 396 (formerly Pathology 369). Genome Editing and Epigenome Editing
Catalog Number: 46863
J. Keith Joung (Medical School) 5149

*Genetics 397. Immunogenomics
Catalog Number: 95934
Soumya Raychaudhuri (Medical School) 2624

*Genetics 398. Epigenetic regulation in stem cell/development & disease
Catalog Number: 48404
Yi Zhang (Medical School) 7196

Quarter Courses for Graduate Students Only

*Genetics 300qc. Advanced Topics in Genetics
Catalog Number: 84294
David Lopes Cardozo (Medical School) 5995
A series of reading and discussion seminars, each running for a half term (7 weeks).
Note: Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 617-432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*Genetics 302qc. Teaching 101: Bringing Effective Teaching Practices to your Classroom
Catalog Number: 91159 Enrollment: Limited to 15.
Fred Winston (Medical School) 7877, Johanna Gutlerner (Medical School), and Henrike Besche (Medical School)
Quarter course (spring term). Th., 1-3:30.
Survey basics of effective teaching practices, focusing on practical application and real-life examples. Topics include effective lecturing techniques, using goals and learning styles to inform lesson planning and design, assessing student understanding, and facilitating discussions.

*Genetics 390qc. Advanced Experimental Methods: Experimental Approaches in Genetic Analysis
Catalog Number: 8039 Enrollment: Limited to 8.
Fred Winston (Medical School) 7877 and members of the Department
Quarter course (spring term). M. through F., 8:30-4. January Course.
A survey of major themes in genetics combined with exposure to various experimental techniques, technologies, and model systems. Combines lectures and hands-on laboratory activities emphasizing experimental methods, hypothesis generation and testing, and data analysis.
Note: Priority will be given to first year graduate students. Students must first contact the faculty for enrollment approval prior to registration for the course. Meeting Dates/Times: Approximately 8:30 am-4:00 pm each day for 10 days from January 6th - January 19th, 2014.
Prerequisite: Students must also enroll in, or have taken, Genetics 201.

*Genetics 391qc. Advanced Experimental Design in Genetics
Catalog Number: 70918 Enrollment: Limited to 8.
Fred Winston (Medical School) 7877 and members of the Department
Quarter course (spring term). M. through F., 8:30-4. January Course.
To be run concurrently with Genetics 390qc. Students will have the opportunity to design experimental approaches that aim to answer specific questions in the field of genetics. Combined with the hands-on laboratory experience of Genetics 390qc, students will use their knowledge of experimental methods and data analysis with a variety of model organisms and techniques. Over the two-week course period, students will be asked to reflect daily on their experiences and design two unique experiments that will broaden their experience in the areas of hypothesis testing and data interpretation.
Note: Must be taken concurrently with Genetics 390qc. Priority will be given to first year graduate students. Students must first contact the faculty for enrollment approval prior to registration for the course. Approximately 8:30am - 4:00pm each day for 10 days from January 6 - January 19, 2014.
Prerequisite: Students must also enroll in, or have taken, Genetics 201.

Human Biology and Translational Medicine

Human Biology and Translational Medicine (HBTM) focuses on providing rigorous multidisciplinary training in the fundamental mechanisms and essential methodologies of human biology and disease-oriented research, and in the translation of these discoveries into advances in the diagnosis, prevention, and treatment of human disease.

Primarily for Graduates

HBTM 200. Principles and Practice of Human Pathology
Catalog Number: 10575 Enrollment: Enrollment may be limited
Constance L. Cepko (Medical School)
Half course (spring term). Tu., Th., 9–11, and lab Th., 11-1. EXAM GROUP: 2
Overview of human pathology, emphasis on mechanisms of disease and modern diagnostic technologies. Integrated lectures, labs, and student-driven term project leading to formal presentation on a medical, socioeconomic, or technological issue in human pathology.
Note: Jointly offered with HMS as HT035.0

[HBTM 201 (formerly Pathology 209). Tumor Pathophysiology and Transport Phenomena - A Systems Biology Approach]
Catalog Number: 5934
Rakesh K. Jain (Medical School)
Half course (fall term). M., 5-7.
Tumor pathophysiology plays a central role in the growth, metastasis, detection, and treatment of solid tumors. Principles of transport phenomena are applied to develop a quantitative understanding of tumor biology and treatment.
Note: Expected to be given in 2015–16. Expected to be given in 2015-2016. Given alternate years with Cell Biology 212. Offered jointly with the Medical School as CB 704.0.

HBTM 235 (formerly BCMP 235). Principles of Human Disease: Physiology and Pathology
Catalog Number: 82892 Enrollment: Will be limited.
Constance L. Cepko (Medical School), and members of the Medical School
Half course (fall term). M., W., F., 9–10:30. EXAM GROUP: 10
This course covers the normal physiology and pathophysiology of selected organs, through lectures, readings, tutorials based on clinical cases, and patient presentations. Human biology is emphasized, with some examples also drawn from model organisms.
Note: Course enrollment will be limited, with priority given to graduate students and a maximum of 10 undergraduates (priority given to seniors).
Prerequisite: Knowledge of introductory biochemistry, molecular biology, and cell biology required (MCB52 and MCB54 or equivalent and one year of organic chemistry for undergraduates).

Graduate Courses of Reading and Research

*HBTM 304. Resolution of Lung Inflammation and Injury
Catalog Number: 1421
Bruce D. Levy (Medical School) 5922

*HBTM 305. Endothelial Cell, Nitric Oxide, Proteomic Redox Regulation
Catalog Number: 9077
Joseph Loscalzo (Medical School) 5923

*HBTM 307. Mechanisms of heart growth, regeneration, and failure
Catalog Number: 1294
Anthony Rosenzweig (Medical School) 5925

*HBTM 314. Skin Immunology T Cell Trafficking Lymphoma
Catalog Number: 2368
Thomas Seth Kupper (Medical School) 5960

*HBTM 315. Hypothalamic Gene Function and Regulation
Catalog Number: 1577
Joseph A. Majzoub (Medical School) 1875

*HBTM 317. Adhesion, Integrins, Hematopoiesis, Kidney Genetics
Catalog Number: 5746
M. Amin Arnaout (Medical School) 1822

*HBTM 320. Endothelial Progenitors in Health Disease
Catalog Number: 8324
Joyce E. Bischoff (Medical School) 1448

*HBTM 321. Regenerative Biology
Catalog Number: 58335
Richard T. Lee 6168

*HBTM 322. Cardiac Repair and Regeneration
Catalog Number: 4398
Ronglih Liao (Medical School) 6169

*HBTM 323. Cardiovascular Biology in Human and Zebrafish
Catalog Number: 5160
Calum Archibald MacRae (Medical School) 6170

*HBTM 324. Principles/Practices of Developing Human Antibody Therapies
Catalog Number: 3910
Wayne A. Marasco (Medical School) 6171

*HBTM 325. Genetics of Blood Development
Catalog Number: 7279
Barry Htin Paw (Medical School) 6172

*HBTM 326. Human Genetics of Neuroinflammatory and Neurodegenerative Disorders
Catalog Number: 1515
Philip Lawrence De Jager (Medical School) 6233

*HBTM 327. Translational Research on Kinase Inhibitors
Catalog Number: 0138
Pasi Antero Janne (Medical School) 6234

*HBTM 328. Translational immunology in immunocompromised hosts
Catalog Number: 8917
Ofer Levy (Medical School) 6236

*HBTM 329. Developing Targeted Therapies for Cancer
Catalog Number: 49916
Jeffrey Adam Engelman (Medical School) 6225

*HBTM 331. Tumor Microenvironment, Angiogenesis and Metastasis: from Bench-to-Bedside-to-Biomarkers
Catalog Number: 8347
Rakesh K. Jain (Medical School) 2079

*HBTM 340. (LHB). Disease-Centered Tutorial Clinics
Catalog Number: 8640 Enrollment: Limited to LHB students only.
Jordan A. Kreidberg (Medical School) 2080
Half course (spring term). .

*HBTM 341. Gene Regulation of Metabolism in Cardiovascular Health and Disease
Catalog Number: 99499
Zoltan Pierre Arany (Medical School) 6409

*HBTM 342. Research in Hematology and Oncology
Catalog Number: 47977
Benjamin L. Ebert (Medical School) 6410

*HBTM 343. Complex Trait Genetics of Blood Pressure and QT Interval Variation
Catalog Number: 63084
Christopher Holmes Newton-Cheh (Medical School) 6270

*HBTM 345. Tuberous Sclerosis and LAM: Pathogenic Mechanisms
Catalog Number: 91208
Elizabeth Petri Henske (Medical School) 6579

*HBTM 346. Bioimaging and Optical Spectroscopy: Detection of Early Disease with Light
Catalog Number: 79138
Lev T. Perelman (Medical School) 6601

*HBTM 347. Effects of Diabetes, Exercise, and Skeletal Muscle Metabolism
Catalog Number: 73142
Laurie Joy Goodyear (Medical School) 3231

*HBTM 348. Molecular Pathogenesis of the Metabolic Syndrome
Catalog Number: 44412
Sudha Biddinger (Medical School) 2628

*HBTM 349. Network Medicine in Vascular Disease
Catalog Number: 14556
Stephen Y. Chan (Medical School) 7011

*HBTM 350. Molecular basis of hematologic and solid cancers
Catalog Number: 61555
Roberto Chiarle (Medical School) 7016

*HBTM 351. Biology and Immunotherapy of Chronic Lymphocytic Leukemia
Catalog Number: 49316
Catherine Ju-Ying Wu (Medical School) 7060

*HBTM 352 (Formerly Pathology 310). Regulation of Vascular Development and Pathology
Catalog Number: 28771
Patricia A. D’Amore (Medical School) 1168

*HBTM 353 (formerly Pathology 313). Mechanobiology and Developmental Control
Catalog Number: 82486
Donald E. Ingber 2832

*HBTM 354 (formerly Pathology 317). Epithelial:stromal Interactions in the Formation and Progression of Carcinomas
Catalog Number: 64171
Antoine Karnoub (Medical School) 6458

*HBTM 355 (formerly Pathology 377). Epigenetic Mechanisms in Mammalian Development
Catalog Number: 42288
Bradley E. Bernstein (Medical School) 5669

*HBTM 356 (formerly Pathology 327). Genetic Models of Leukemogenesis
Catalog Number: 86835
A. Thomas Look (Medical School) 3771

*HBTM 358 (formerly Pathology 332). Control of Cell Proliferation by RB/E2F
Catalog Number: 33855
Nicholas J. Dyson (Medical School) 1829

*HBTM 359 (formerly Pathology 333). Genetics of Neurodegenerative Disease
Catalog Number: 99808
Mel B. Feany (Medical School) 4439

*HBTM 360 (formerly Pathology 334). Characterization of Molecular Targets of Cancer Therapy
Catalog Number: 25971
Daniel A. Haber (Medical School) 1832

*HBTM 361 (formerly Pathology 335). Molecular Approaches to Cell Immortalization and Transformation
Catalog Number: 39571
William C. Hahn (Medical School) 4317

*HBTM 362 (formerly Pathology 350). Topics in Vascular Biology
Catalog Number: 14796
Michael A. Gimbrone (Medical School) 1896

*HBTM 363 (formerly Pathology 352). Recombination Functions of the BRCA Genes
Catalog Number: 22147
Ralph Scully (Medical School) 4536

*HBTM 364 (formerly Pathology 359). Signal Transduction Pathways Involved in Cellular Proliferation and Apoptosis
Catalog Number: 14536
Roya Khosravi-Far (Medical School) 2704

*HBTM 365 (formerly Pathology 360). Biology and Genetics of Human Cancers
Catalog Number: 37417
Matthew L. Meyerson (Medical School) 2421

*HBTM 366 (formerly Pathology 364). Molecular Genetics of Erythroid Iron Metabolism
Catalog Number: 22101
Mark Daniel Fleming (Medical School) 4955

*HBTM 367 (formerly Pathology 365). Control of Endothelial Cell Fate and Vascular Development by Fluid Mechanical Forces
Catalog Number: 57098
Guillermo Garcia-Cardena (Medical School) 4956

*HBTM 369 (formerly Pathology 372). DNA Damage Responses and Genomic Stability
Catalog Number: 54705
Lee Zou (Medical School) 5258

*HBTM 370 (formerly Pathology 373). Integration of Metabolism and Stress Pathways
Catalog Number: 39025
Nika Danial (Medical School) 5393

*HBTM 371 (formerly Pathology 374). Cell signaling in innate immunity
Catalog Number: 27824
Hongbo Luo (Medical School) 5395

*HBTM 372 (formerly Pathology 378). Epigenetic Regulation in Development and Disease
Catalog Number: 55243
Laurie Jackson-Grusby (Medical School) 5671

*HBTM 373 (formerly Pathology 382). Mechanisms of Acute and Chronic Allograft Rejection
Catalog Number: 27268
Richard N. Mitchell (Medical School) 5916

*HBTM 374 (formerly Pathology 383). Cell Cycle, Ubiquitination and Protein Degradation, Cancer Research
Catalog Number: 62612
Wenyi Wei (Medical School) 5918

*HBTM 375 (formerly Pathology 384). The Molecular Genetics of Human Cancer
Catalog Number: 50657
Pier Paolo Pandolfi (Medical School) 6177

*HBTM 376 (formerly Pathology 386). Hematopoietic stem cell biology and aging
Catalog Number: 28486
Derrick J. Rossi 6330

*HBTM 377 (formerly Pathology 388). Impact of Epigenetics On Cellular Homeostasis
Catalog Number: 30031
Johnathan Whetstine (Medical School) 6244

*HBTM 378. Inherited basis for myocardial infarction
Catalog Number: 95712
Instructor to be determined

*HBTM 379. Molecular pathogenesis of pediatric cancer
Catalog Number: 18969
Rani E. George (Medical School) 7428

*HBTM 380. Gene Therapy Translation and Vector Development
Catalog Number: 14087
Luk Hugo Vandenberghe (Medical School) 7356

*HBTM 381. Neurodevelopmental and neurodegenerative disorders
Catalog Number: 92899
Tracy Pearse (Medical School) 7417

Quarter Courses for Graduate Students Only

*HBTM 300qc. Advanced Topics in Human Biology and Translational Medicine
Catalog Number: 32772
David Lopes Cardozo (Medical School) 5995
A series of reading and discussion seminars, each running for a half term (7 weeks).
Note: Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 617-432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*HBTM 301qc. Case Studies in Human Biology and Translational Medicine
Catalog Number: 95905 Enrollment: Will be limited.
Caren Grossbard Solomon (Medical School) 6960 and Mary Elizabeth Hamel (Medical School)
Quarter course (spring term). M. through F., 9–10:30.
Two-week course that is required of and restricted to first-year LHB students. Each week of the course focuses on a different "case study" in translational medicine.
Note: January term course. Restricted to Leder students only.

*HBTM 302qc. Imaging and Microscopy Methods in Biology and Medicine
Catalog Number: 13534 Enrollment: Limited to 12.
Lev T. Perelman (Medical School) 6601
Quarter course (fall term). T., 3-5.
Introduce modern imaging modalities with emphasis on modalities frequently employed in cellular, molecular biology and medicine. Overview of noninvasive medical imaging techniques frequently used in scientific research: X-ray CT, MRI, ultrasound, PET/SPECT and optical imaging.

*HBTM 303qc. Vision: A System and its Assessment
Catalog Number: 65449
Patricia A. D’Amore (Medical School) 1168 and Russell L. Woods (Medical School)
Quarter course (fall term). W., 3–5.
This course provides an introduction to the visual system and its assessment. In general, we will consider vision as a system rather than its low-level components. Each two-hour session consists of two lectures provided by faculty with expertise in that area. Topics will include basic science and clinical topics, normal vision and abnormal vision, methods of assessment of animals and humans, clinical and laboratory measures.

[*HBTM 304qc. Drug Development: From Concept to Commercialization]
Catalog Number: 83871 Enrollment: Limited to 30.
Michael Goldberg (Medical School) 7037
Quarter course (spring term). Tu., 5–7 p.m.
This course is intended to provide graduate students with exposure to the diverse aspects of the drug development process. The novel cystic fibrosis drug Kalydeco will be used as an exemplar, though the themes of discovery, development, manufacturing, business development, commercialization, and growth are relevant across most therapeutics. Each class will include a lecture by a person involved in that particular aspect of Kalydeco development followed by a group discussion of the associated case study.
Note: Expected to be given in 2015–16.

*HBTM 305qc (formerly *Pathology 301qc). The Molecular Bases of Eye Disease
Catalog Number: 85085
Darlene Ann Dartt (Medical School) 6904 and Magali Saint-Geniez (Medical School)
Quarter course (spring term). M., 3–5.
Understanding of the molecular bases for diseases that target the eye.

Immunology

All courses in Immunology are subject to limitation in enrollment and will not be offered unless there is sufficient demand.

Primarily for Graduates

*Immunology 201. Principles of Immunology
Catalog Number: 8337 Enrollment: Limited to 50.
Michael C. Carroll (Medical School), Ulrich H. Von Andrian-Werburg (Medical School) and members of the Program in Immunology
Half course (fall term). Tu., Th., 1:30-3, with section Tu., Th., 3-4. EXAM GROUP: 8
Comprehensive core course in immunology. Topics include a broad but intensive examination of the cells and molecules of the immune system. Special attention given to the experimental approaches that led to general principles of immunology.
Note: Intended for students who have had prior exposure to immunology on the undergraduate level. In the absence of such exposure, students must obtain the permission of the Course Director. Offered jointly with the Medical School as IM 702.0.
Prerequisite: A background in genetics and biochemistry strongly recommended.

Immunology 202. Advanced Principles of Immunology
Catalog Number: 5674
D. Branch Moody (Medical School) and Martin E. Hemler (Medical School)
Half course (spring term). Tu., Th., 1:30–4. EXAM GROUP: 1
Continuation of Immunology 201 as an intensive core course in fundamentals of immune system, emphasis of physiological roles of immune cells in vivo. Classes taught by experts in their fields; involve critical reading of primary literature.
Note: Offered jointly with the Medical School as IM 712.0.
Prerequisite: Immunology 201 or its equivalent.

Immunology 204. Critical Readings for Immunology
Catalog Number: 9563
Florian Winau (Medical School)
Half course (spring term). Th., 10-1. EXAM GROUP: 12
Original research articles from fields including immunology, biochemistry, genetics, and cell and developmental biology will be critically analyzed in an intensive small group format. Grading will be based on class participation and oral presentations.
Note: Required for first-year immunology students, open to second-year immunology students. No auditors. Offered jointly with the Medical School as IM 703.0.

Graduate Courses in Reading and Research

Primarily designed for work on a dissertation problem, carried out under the supervision of the following faculty members whose special research interests are listed.
*Immunology 300. Advanced Topics in Immunology
Catalog Number: 4739
David Lopes Cardozo (Medical School) 5995
Reading and discussion seminars each running for a half term (7 weeks). Two seminars, which can be taken in different terms, are required for credit. Topics include the role of intracellular and transmembrane protein phosphates in signal transduction.
Note: Intended for first- and second-year Immunology graduate students. Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Call 617-432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*Immunology 301. Immunology Seminar
Catalog Number: 4971 Enrollment: Limited to 20.
Michael C. Carroll (Medical School) 2050 and William Nicholas Haining (Medical School) 6946
Half course (fall term; repeated spring term). W. 12:15-1:15 (lunch) and 3:30-5 (discussion).
Gives students exposure to research topics in Immunology. Students prepare for the weekly seminar through readings, discussions, and preparing brief write-ups. These discussions are facilitated by members of the Committee on Immunology.
Note: Required for, and limited to, first-year Immunology graduate students.

*Immunology 302. Innate and adaptive immune inflammation in allergic and asthmatic models
Catalog Number: 1355
K. Frank Austen (Medical School) 6887

*Immunology 303. Immunity to Tuberculosis
Catalog Number: 9490
Samuel M. Behar (Medical School) 4570

*Immunology 304. Innate immunity and host-pathogen interactions
Catalog Number: 62634
Lynda Stuart (Medical School) 6466

*Immunology 305. T Cell Immunology - tolerance, transplantation, autoimmunity
Catalog Number: 74626
Laurence A. Turka (Medical School) 2633

*Immunology 309. Molecular Aspects of Lymphocyte Interactions
Catalog Number: 3778
Cox Terhorst (Medical School) 6280

*Immunology 310. Responses mediated by innate and adaptive immune cells in cancer and other inflammatory disorders
Catalog Number: 53318
Mikael J. Pittet (Medical School) 2641

*Immunology 311. Macrophage biology in multiple contexts, including IBD and metabolism
Catalog Number: 93003
Tiffany Horng (Public Health) 6612
Half course (spring term). .

*Immunology 312. Interplay Between the Innate Immune System and Gut Microbial Communities
Catalog Number: 11923
Wendy S. Garrett (Public Health) 6613

*Immunology 314. Rheumatic Diseases
Catalog Number: 8065
Peter H. Schur (Medical School) 4551

*Immunology 315. Immunoregulation
Catalog Number: 5540
Martin E. Dorf (Medical School) 4541

*Immunology 316. Molecular Basis of Immunologic Recognition and Communication
Catalog Number: 3192
Harvey Cantor (Medical School) 4460

*Immunology 317. Molecular Biology of Receptor Transduction in the Immune System
Catalog Number: 0518
Brian Seed (Medical School) 7619

*Immunology 318. Mechanisms of Antigen Presentation and Cellular Immunology
Catalog Number: 23104
Florian Winau (Medical School) 2639

*Immunology 319. Molecular Basis of Cell Adhesion and Migration
Catalog Number: 0293
Timothy A. Springer (Medical School) 6145

*Immunology 320. Cell Adhesion in Vascular Biology and Innate Immunity
Catalog Number: 85446
Denisa D. Wagner (Medical School) 2092

*Immunology 320L. The study of human tissue resident T cells
Catalog Number: 86176
Rachael Ann Clark (Medical School) 3429

*Immunology 321. Why functional memory T cells are formed, and why protective T cell immunity fails to develop against chronic viral infection and cancer
Catalog Number: 15497
William Nicholas Haining (Medical School) 6946

*Immunology 321L. The molecular mechanism of immunity to fungal pathogens.
Catalog Number: 46538
Jatin Mahesh Vyas (Medical School) 7055

*Immunology 322. Systems Approaches to Innate and Adaptive Immunity; Functional Genomics of Complex Disease Genetics
Catalog Number: 12714
Ramnik Xavier (Medical School) 6878

*Immunology 322L. Molecular and cellular analysis of primary immunodeficiencies
Catalog Number: 79856
Luigi D. Notarangelo (Medical School) 6666

*Immunology 323L. Immunity to bacterial enteropathogens: modulation by host and microbial factors
Catalog Number: 47426
Bobby J. Cherayil (Medical School) 7014

*Immunology 324. T-cell Development in Animal Models of Autoimmunity Disease
Catalog Number: 1905
Christophe O. Benoist (Medical School) 3928

*Immunology 324L. T cell sensitization and immunoregulation in ocular allo- and autoimmunity
Catalog Number: 38401
Reza Dana (Medical School) 7164

*Immunology 325. Immune Cell Interactions Controlling T Cell Effector Function
Catalog Number: 1078
Thorsten Roman Mempel (Medical School) 6173

*Immunology 325L. Mechanisms of Peripheral Tolerance and Their Breakdown in Allergic and Autoimmune Diseases
Catalog Number: 46639
Talal Amine Chatila (Medical School) 7126

*Immunology 326. Human T-cell Antigen Receptor; Human Lymphocyte Differentiation Antigens; TCR; Thymic Development; Protective Immunity; HIV-I; T-cell Vaccines
Catalog Number: 6719
Ellis L. Reinherz (Medical School) 1408

*Immunology 326L. Mechanistic elucidation of immune signaling
Catalog Number: 86626
Hao Wu (Medical School)

*Immunology 327. Chemical Cell Biology
Catalog Number: 0824
Stuart L. Schreiber 2166

*Immunology 327L (formerly *HBTM 368). Phagocyte-endothelial Cell Responses in Inflammation
Catalog Number: 28559
Tanya Mayadas (Medical School) 4963

*Immunology 328r. Introduction to Research
Catalog Number: 5531
Michael C. Carroll (Medical School) 2050

*Immunology 329. Basic and Clinical Mechanisms of Autoimmunity
Catalog Number: 0354
Howard L. Weiner (Medical School) 1335

*Immunology 329L. Examining the interplay of inflammation and glycosylation
Catalog Number: 20965
Robert Anthony (Medical School) 7201

*Immunology 330. Molecular Aspects of Mast Cells—Mediated Immune Responses
Catalog Number: 7296
Richard L. Stevens (Medical School) 2892

*Immunology 330L. CD4+ T Cell Tolerance
Catalog Number: 55675
James J. Moon (Medical School) 7251

*Immunology 331. Lymphoid Organs
Catalog Number: 5725
Joan E. Stein-Streilein (Medical School) 4769

*Immunology 332. The Role of Cysteinyl Leukotrienes and their Receptors in Pulmonary Inflammation and Fibrosis
Catalog Number: 9530
Yoshihide Kanaoka (Medical School) 5401

*Immunology 334. Understanding the Mechanisms of Pathogen-sensing by the Innate Immune System
Catalog Number: 11337
Terry K. Means (Medical School) 6898

*Immunology 336. T-Lymphocyte Recognition
Catalog Number: 7292
Michael B. Brenner (Medical School) 2864

*Immunology 337. Study of the influence of initial bacterial colonization on the development of the mucosal immune system
Catalog Number: 1320
W. Allan Walker (Medical School, Public Health) 1175

*Immunology 337L. Vascular and Cell Biology of Inflammation and Wound Healing
Catalog Number: 36804
Christopher Vincent Carman (Medical School) 7438

*Immunology 339. Function and Regulation of Cellular Adhesion Mechanisms
Catalog Number: 7841
Martin E. Hemler (Medical School) 2868

*Immunology 340. The Human Major Histocompatibility Complex, Immune Function, and Disease
Catalog Number: 6650
Chester Alper (Medical School) 2951

*Immunology 341. Gene Regulation in Normal and Leukemic Stem Cells
Catalog Number: 9403
Daniel G. Tenen (Medical School) 1172

*Immunology 342. Immune Cell Signaling, Gene Transcription and Tissue Injury in Lupus.
Catalog Number: 7829
George C. Tsokos (Medical School) 5911

*Immunology 343. The Regulation of Eicosanoid Generation
Catalog Number: 8593
Jonathan P. Arm (Medical School) 4946

*Immunology 344. Genetic Analysis of Lymphocyte Development and Nuclear Oncogene Function
Catalog Number: 6438
Frederick W. Alt (Medical School) 3146

*Immunology 345. Assembly and Function of pre-B Cell-fate and B Lymphocyte Antigen Receptors
Catalog Number: 0866
Shiv S. Pillai (Medical School) 3393

*Immunology 346. Trafficking of antigen in lymph nodes
Catalog Number: 1755
Michael C. Carroll (Medical School) 2050

*Immunology 348. Cell Biology, Biochemistry, and Immunology of Leukocyte-endothelial Adhesion
Catalog Number: 0901
Francis W. Luscinskas (Medical School) 3772

*Immunology 350. Regulation of Autoimmune T Cell Responses
Catalog Number: 1916
Vijay K. Kuchroo (Medical School) 2041

*Immunology 351. Investigating the Role of Lectin - Carbohydrate Interactions in T Cell Trafficking and Differentiation and in Tumor Immune Evasion
Catalog Number: 1875
Charles J. Dimitroff (Medical School) 5521

*Immunology 353. Innate and Adaptive Immune Responses in HIV-1 Infection
Catalog Number: 6000
Marcus Altfeld (Medical School) 5689

*Immunology 354. Topics in Transplantation Biology
Catalog Number: 1459
David H. Sachs (Medical School) 1075

*Immunology 355. Molecular mechanisms of antigen presentation
Catalog Number: 59519
Edda Fiebiger (Medical School) 2631

*Immunology 356. Cytotoxic T Lymphocytes
Catalog Number: 8232
Judy Lieberman (Medical School) 1542

*Immunology 357. Microbial-epithelial-immune Cell Interactions in Mucosal Tissues
Catalog Number: 2111
Richard S. Blumberg (Medical School) 2351

*Immunology 359. Immunoregulatory Mechanisms at Mucosal Surfaces, Including the Lung and Gut, Affecting the Development of Inflammation, Allergy, Asthma or Peripheral Tolerance in Mice and Humans.
Catalog Number: 3037
Dale T. Umetsu (Medical School) 5289

*Immunology 360. Hematopoietic Stem Cells and their Niche
Catalog Number: 8952
David T. Scadden 2649

*Immunology 361. Induction and Regulation of Antigen-specific T Cell Responses
Catalog Number: 7578
Gilles A. Benichou (Medical School) 2652

*Immunology 362. Chemokine and Lipid Chemoattractants in Immune Cell Trafficking in Normal Physiology and Disease
Catalog Number: 3817
Andrew D. Luster (Medical School) 2654

*Immunology 363. Regulation of Immune and Inflammatory Responses by the Leukocyte Immunoglobulin-like Receptor Family
Catalog Number: 6813
Howard R. Katz (Medical School) 2837

*Immunology 364. T-cell Differentiation, Tolerance and Autoimmunity
Catalog Number: 0972
Diane J. Mathis (Medical School) 3063

*Immunology 366. Immune Mechanisms in Cardiovascular Disease
Catalog Number: 6676
Andrew H. Lichtman (Medical School) 3523

*Immunology 367. Biology and Chemistry of Complement Problems
Catalog Number: 8080
Anne Nicholson-Weller (Medical School) 1063

*Immunology 368. RNA Granules
Catalog Number: 8986
Paul J. Anderson (Medical School) 1947

*Immunology 369. Mechanisms of Autoimmune Disease
Catalog Number: 6787
Vicki R. Kelley (Medical School) 2656

*Immunology 371. Cellular and Molecular Mechanisms of Eosinophil and Other Leukocyte Involvement in Allergic Flammation
Catalog Number: 3716
Peter F. Weller (Medical School) 2657

*Immunology 372. Immunopathogenesis & regulation of immune response in EAE
Catalog Number: 34969
Samia Joseph Khoury (Medical School) 6948

*Immunology 373. Biology of Histocompatibility Systems in Man and Experimental Animals; Immunology of Aging
Catalog Number: 6317
Edmond J. Yunis (Medical School) 6036

*Immunology 374. Tumor Necrosis Factor-Alpha Gene Regulation in the Immunopathogenesis of AIDS and TB
Catalog Number: 4558
Anne E. Goldfeld (Medical School) 1008

*Immunology 375. Biology and Function of Immunoreceptors
Catalog Number: 0510
Jean-Pierre Kinet (Medical School) 2663

*Immunology 376. Molecular Basis of Immunodeficiencies; Immunological and Molecular Basis of Atopic Dermatitis
Catalog Number: 3618
Raif S. Geha (Medical School) 1795

*Immunology 378. T cell Biology and Cancer Immunology
Catalog Number: 2916
Kai Wucherpfennig (Medical School) 2481

*Immunology 380. Control of Leukocyte Trafficking and the Immune Response By Chemokines and Other Cytokines
Catalog Number: 4872
Barrett J. Rollins (Medical School) 3775

*Immunology 382. AIDS Immunopathogenesis and Immune Reconstitution
Catalog Number: 0468
Robert P. Johnson (Medical School) 6125

*Immunology 384. The Role of Cysteinyl Leukotrienes and Nucleotide Receptors in Control of Pulmonary Allergic Immunity
Catalog Number: 1056
Joshua A. Boyce (Medical School) 6230

*Immunology 385. Regulation of T Lymphocyte Activation and Differentiation
Catalog Number: 1243
I-Cheng Ho (Medical School) 2764

*Immunology 386. Molecular and signaling pathways regulating T cell immunity and T cell anergy
Catalog Number: 35936
Vassiliki A. Boussiotis (Medical School) 6879

*Immunology 389. Development of Cancer Vaccines
Catalog Number: 4106
Glenn Dranoff (Medical School) 1821

*Immunology 390. The Role of NK Cells in Tissues
Catalog Number: 87458
Galit Alter (Medical School) 6760

*Immunology 391. Transcription Factors in Lymphocyte Commitment and Differentiation
Catalog Number: 5285
Katia Georgopoulos (Medical School) 2070

*Immunology 392. Dendritic Cells and the Initiation of Immune Reponses; Genetic Analysis using Genome-Wide Mammalian RNAi Libraries
Catalog Number: 0298
Nir Hacohen (Medical School) 5157

*Immunology 393. The Role of the Transcription Factor NF-kB in Regulating Innate Inflammatory Responses
Catalog Number: 3287
Bruce H. Horwitz (Medical School) 5158

*Immunology 394. Cytotoxic Lymphocytes
Catalog Number: 0938
D. Branch Moody (Medical School) 5159

*Immunology 395. NKT and Other Immune Cell Subsets in Anti-Tumor & Anti-Viral Immunity
Catalog Number: 2491
Mark Adrian Exley (Medical School) 5749

*Immunology 396. Interested in Immune Tolerance, Particularly in Settings of Autoimmunity and Transplantation.
Catalog Number: 1812
Terry B. Strom (Medical School) 5160

*Immunology 397. Antigen Processing and Presentation by Dendritic Cells in Autoimmunity and Cancer
Catalog Number: 3393
Shannon Turley (Medical School) 5255

*Immunology 398. The Role of Notch Signaling in Lymphoid Neoplasia
Catalog Number: 9151
Jon Christopher Aster (Medical School) 5750

Quarter Courses for Graduate Students Only

*Immunology 300qc. Advanced Topics in Immunology
Catalog Number: 99401
David Lopes Cardozo (Medical School) 5995
A series of reading and discussion seminars, each running for a half term (7 weeks).
Note: Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 617-432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*Immunology 301qc. Autoimmunity
Catalog Number: 69978
Kai Wucherpfennig (Medical School) 2481, Vijay K. Kuchroo (Medical School)
Quarter course (fall term). M., 4–6.
This course will focus on basic immunological mechanisms of autoimmune diseases, with an emphasis on recent advances in the field. At each session, we will focus on a particular topic and discuss three important publications.
Note: Offered in alternate years.

*Immunology 302qc. Clinical Sessions
Catalog Number: 40428
Rachael Ann Clark (Medical School) 3429
Quarter course (spring term). T., 12-1.
Lectures by physician scientists and clinical exposure to patients with immunologically mediated diseases. The goal is to foster translational research into human immunologic disease.
Note: Limited to Immunology students.

*Immunology 303qc. The Warring Genomes: Innate Immunity and Host Defense
Catalog Number: 55535
Jonathan C. Kagan (Medical School) 6235
Quarter course (spring term). M., 4–6.
Focus on basic cellular and molecular aspects of innate immunity, with an emphasis on recent advances in the field. Each class will cover a specific topic, and supporting literature will be provided by the instructor.
Prerequisite: Students are expected to have already taken IMM201.

*Immunology 304qc. Current Concepts in Mucosal Immunology
Catalog Number: 25936
J. Rodrigo Mora (Medical School) and Scott Snapper (Medical School)
Quarter course (spring term). Hours to be arranged.
Innate and adaptive immune mechanisms operating at mucosal surfaces and their interplay under normal and pathological conditions.

*Immunology 305qc. Neuro-immunology in Development, Regeneration and Disease
Catalog Number: 98545
Beth Stevens (Medical School) 6678
Quarter course (spring term). (Th.), 5–7.
It is increasingly clear that the nervous system and immune system share parallel molecular pathways, and communication between neurons and immune cells play significant roles in homeostasis and disease. This course will investigate current topics in neuro-immunology: CNS development, chronic pain, neuro-degeneration, aging, axon regeneration, auto-immunity and infection. We will focus our discussions on molecular mechanisms shared by the immune and nervous systems and the molecular cross-talk between these two systems.
Note: Each class will cover a specific topic in neuro-immunology. Students should be prepared to lead discussions on pre-selected papers for each session.

*Immunology 306qc. Systems Immunology
Catalog Number: 87129
Nir Hacohen (Medical School) 5157, William Nicholas Haining (Medical School), Christophe O. Benoist (Medical School), and visiting speakers
Quarter course (spring term). F., 9–11.
Our focus in this course is on the emerging field of systems immunology. Each session will review a class of experimental approaches, followed by a critical discussion of illustrative papers. Hands-on workshops will introduce students to computational tools for analyzing large-scale datasets, focusing on gene expression.

*Immunology 307qc. Tumor Immunology
Catalog Number: 29695
Kai Wucherpfennig (Medical School) 2481, Glenn Dranoff (Medical School), Shannon Turley (Medical School), Michael Goldberg (Medical School)
Quarter course (fall term). M., 4–6.
There have been many exciting recent developments in the cancer immunology field, and multiple therapeutic approaches have shown efficacy against diverse types of cancer. This course will emphasize new mechanistic insights, in particular on the following topics: Mechanisms of spontaneous protective anti-tumor immunity; Key effector cell populations of anti-tumor immunity; Inflammation and tumor microenvironment; Immunosuppressive mechanisms in tumor immunity; Targeting of inhibitory receptors; Cancer vaccines; New approaches for delivery of immunotherapies into tumors.

Medical Sciences

Primarily for Graduates

*Medical Sciences 250ab. Human Functional Anatomy
Catalog Number: 6946 Enrollment: Limited to 52. This course requires rental of a locker.
Lee Gehrke (Medical School)
Full course (fall term). Lectures, M., W., F., 1:30-2:30; laboratory, M., W., F., 2:30-6. EXAM GROUP: 1
Lectures, detailed laboratory dissections, and prosections provide a thorough exploration of the gross structure and function of the human body. Fundamental principles of embryology and bioengineering promote analytical approaches to understanding the body’s design.
Note: Open to qualified graduate students with permission of the course director. The course has a minimum enrollment of 30. This course requires rental of a locker for two hundred and ten dollars. Offered jointly with the Medical School as HT010.

Graduate Courses of Reading and Research

*Medical Sciences 303. Cancer Genomics
Catalog Number: 25409
Rameen Beroukhim (Medical School) 7235

*Medical Sciences 310. Advanced Topics in Medical Sciences
Catalog Number: 7449
David Lopes Cardozo (Medical School) 5995
A series of reading and discussion seminars, each running for a half term (seven weeks). Different topics are covered each term.
Note: Two seminars, which can be taken in different terms, are required for credit. Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*Medical Sciences 399. Topics in Medical Sciences
Catalog Number: 3197
David Lopes Cardozo (Medical School) 5995
Subject selected by students and faculty member.

Quarter Courses for Graduate Students Only

*Medical Sciences 300qc. Conduct of Science
Catalog Number: 47879
Raju Kucherlapati (Medical School) 4324
Quarter course (fall term). Hours to be arranged .
Note: Restricted to GSAS graduate students on the Longwood campus.

*Medical Sciences 301qc. PATHS courses
Catalog Number: 35301
David Lopes Cardozo (Medical School) 5995
A series of career development PATH courses and discussion seminars. Different topics are covered each term.
Note: Limited to the Division of Medical Sciences students. Not for academic credit towards the PhD degree.

*Medical Sciences 302qc. Conduct of Science Refresher
Catalog Number: 16457
Raju Kucherlapati (Medical School) 4324
Quarter course (fall term). Hours to be arranged.
Note: Restricted to DMS graduate students.

Microbiology and Immunobiology

All courses in Microbiology and Immunobiology are subject to limitation in enrollment and will not be offered unless there is sufficient demand.

Primarily for Graduates

Microbiology 201. Molecular Biology of the Bacterial Cell
Catalog Number: 38739
David Z. Rudner (Medical School), Thomas G. Bernhardt (Medical School), Simon L. Dove (Medical School), and Ann Hochschild (Medical School)
Half course (spring term). Tu., Th., 10–12. EXAM GROUP: 12
This course is devoted to bacterial structure, physiology, genetics, and regulatory mechanisms. The class consists of lectures and group discussions emphasizing methods, results, and interpretations of classic and contemporary literature.

*Microbiology 205. Mechanisms of Microbial Pathogenesis
Catalog Number: 2480 Enrollment: Limited to 40.
Clyde S. Crumpacker II (Medical School) and members of the Department
Half course (fall term). Tu., Th., 8:30-1. EXAM GROUP: 9
The mechanisms of bacterial, mycoplasmal, fungal, and viral pathogenesis are covered. Topics are selected for intrinsic interest and cover the spectrum of pathophysiologic mechanisms of the infectious process. Emphasis on pathogenesis at the molecular level.
Note: Offered jointly with the Medical School as HT 040.
Prerequisite: A background course in molecular biology is strongly encouraged.

*Microbiology 210. Microbial Sciences: Chemistry, Ecology, and Evolution
Catalog Number: 63006 Enrollment: Limited to 30.
Michael S. Gilmore (Medical School)
Half course (spring term). F., at 8:30, F., 9:45–11:45. EXAM GROUP: 10
This is an interdisciplinary graduate-level and advanced undergraduate-level course in which students explore topics in molecular microbiology, microbial diversity, and microbially-mediated geochemistry in depth. This course will be taught by faculty from the Microbial Sciences Initiative. Topics include the origins of life, biogeochemical cycles, microbial diversity, and ecology.
Note: Also offered as Organismic and Evolutionary Biology 290.
Prerequisite: For advanced undergraduates, Life Sciences 1a and 1b are required, or permission of instructor. MCB 52 is recommended.

Microbiology 213. Social Issues in Biology
Catalog Number: 7905 Enrollment: Limited to 20.
Jonathan R. Beckwith (Medical School), and Louis Guenin (Medical School)
Half course (spring term). Th., 1–4. EXAM GROUP: 1
Discussion course on topics selected from the following: history, philosophy of science; evolution vs. creationism; genetics and race; women and science; genetic testing; science journalism; genetics and criminality; science in wartime; scientists and social responsibility; theater and the public presentation of science.
Note: Offered jointly with the Medical School as MG 722.0. Alternates yearly between the Longwood and the Cambridge Campuses.
Prerequisite: Some background in genetics.

Microbiology 214. Mechanisms of Bacterial Pathogenesis and Host Immune Response - (New Course)
Catalog Number: 37145
Marcia Goldberg (Medical School), Jonathan C. Kagan (Medical School), and Michael Starnbach (Medical School)
Half course (fall term). Tu., Th., 10–12. EXAM GROUP: 12
This course focuses on molecular mechanisms of bacterial pathogenesis and the host response to infection. The class consists of lectures and group discussions emphasizing methods, results, and interpretations of classic and contemporary literature. The course is designed to complement Microbiology 201.

Graduate Courses of Reading and Research

Primarily designed for work on a dissertation problem, carried out under the supervision of the following faculty members, whose special research interests are listed. Courses in parasitology are listed in the catalog of the Harvard School of Public Health (see Pathology).

*Microbiology 300. Advanced Topics in Microbiology and Molecular Genetics
Catalog Number: 2304
David Lopes Cardozo (Medical School) 5995
A series of reading and discussion seminars, each running for a half term (7 weeks). Two seminars, which can be taken in different terms, are required for credit.
Note: Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 617-432-0605 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.
Prerequisite: Dependent on seminar.

*Microbiology 304. Molecular Pathogenesis of Streptococcal Infection
Catalog Number: 9527
Michael R. Wessels (Medical School) 4540

*Microbiology 305. Molecular Determinants of Intracellular Bacterial Pathogenesis
Catalog Number: 3190
Darren E. Higgins (Medical School) 2963

*Microbiology 308. Bacterial/ Host Interactions in Symbiosis and Pathogenesis
Catalog Number: 4217
Dennis L. Kasper (Medical School) 4815

*Microbiology 310. Bacterial Genetics of Tuberculosis and Tularemia
Catalog Number: 7652
Eric J. Rubin (Medical School) 4084

*Microbiology 312. Acquired and Innate Immunity to Pneumococci
Catalog Number: 78191
Richard Malley (Medical School) 6461

*Microbiology 313. T-Lymphocyte Responses to Bacterial Pathogens
Catalog Number: 4959
Michael Starnbach (Medical School) 1816

*Microbiology 315. Signaling Networks That Regulate Synapse Development
Catalog Number: 58003
Michael E. Greenberg (Medical School) 1400

*Microbiology 316. Host Pathogen Interactions
Catalog Number: 7769
Stephen Lory (Medical School) 4326

*Microbiology 317. Molecular Mechanisms in Pathogenesis
Catalog Number: 8985
John J. Mekalanos (Medical School) 7315

*Microbiology 318. RNA Structure, RNA-protein Interactions, and Translation-level Gene Regulation in RNA Viruses
Catalog Number: 1205
Lee Gehrke (Medical School) 8036

*Microbiology 320. Molecular Biology of Herpes Viruses
Catalog Number: 3967
David M. Knipe (Medical School) 7089

*Microbiology 324. Bacterial Pathogenesis and Vaccine Development
Catalog Number: 3472
Gerald Pier (Medical School) 2853

*Microbiology 325. Signal Transduction, Host-Microbial Interactions and Immunology
Catalog Number: 2839
Scott Brian Snapper (Medical School) 4969

*Microbiology 326. Biology and virulence of enteric pathogens
Catalog Number: 4703
Matthew K. Waldor (Medical School) 5919

*Microbiology 328. Molecular Biology of Epstein Barr Virus Infection and Transformation of B Lymphocytes
Catalog Number: 3188
Elliott D. Kieff (Medical School) 1858

*Microbiology 329. The Regulation of Gene Expression in Pathogenic Bacteria
Catalog Number: 5892
Simon L. Dove (Medical School) 4953

*Microbiology 330. Bacterial chromosome dynamics and cell biology
Catalog Number: 5102
David Z. Rudner (Medical School) 4968

*Microbiology 331. Modeling Mechanisms of Bacterial Pathogenesis
Catalog Number: 1929
Cammie Lesser (Medical School) 4962

*Microbiology 332. Gene Regulation of Prokaryotes
Catalog Number: 0915
Ann Hochschild (Medical School) 2314

*Microbiology 335. Molecular Biology of Parasites
Catalog Number: 0528
Dyann F. Wirth (Public Health) 2492

*Microbiology 336. Pathogen-host Interactions
Catalog Number: 3981
Marcia Goldberg (Medical School) 3783

*Microbiology 337. Mycobacterial Signal Transduction and Transcription Regulation
Catalog Number: 5826
Robert Husson (Medical School) 5914

*Microbiology 339. Bacterial Cell Division and Cell Biology
Catalog Number: 7237
Thomas G. Bernhardt (Medical School) 5752

*Microbiology 341. Molecular Biology Multi-drug Resistant Pathogens
Catalog Number: 88249
Michael S. Gilmore (Medical School) 6227

*Microbiology 343. Chemical Biology, Enzymology, Antibiotics, Glycosyltransferases, Inhibitors
Catalog Number: 2963
Suzanne Walker (Medical School) 5087

*Microbiology 344. Chemistry and Biology of Host-Virus Interactions
Catalog Number: 8853
Priscilla Yang (Medical School) 5156

*Microbiology 346. Genetics of Bacterial Adhesion and Pathogenesis
Catalog Number: 5690
Paula I. Watnick (Medical School) 5666

*Microbiology 347. Chemical Genetics Approach to Bacterial Pathogenesis
Catalog Number: 2308
Deborah Tan Hung (Medical School) 5701

*Microbiology 348. Toll-like Receptors and Innate Immunity
Catalog Number: 9708
Jonathan C. Kagan (Medical School) 6235

*Microbiology 349. Molecular Mechanisms of Leukocyte Trafficking
Catalog Number: 10956
Ulrich H. Von Andrian-Werburg (Medical School) 2090

*Microbiology 350. Regulation of T-cell Mediated Immune Response
Catalog Number: 77585
Arlene H. Sharpe (Medical School) 1588

*Microbiology 351. Viral Pathogenic and Transformation Mechanisms
Catalog Number: 92692
Peter M. Howley (Medical School) 1076

*Microbiology 352. The Biology of microRNAs and their Dysregulation in Cancers
Catalog Number: 56277
Carl D. Novina (Medical School) 5356

*Microbiology 353. Development and delivery of RNA therapeutics
Catalog Number: 43059
Michael Goldberg (Medical School) 7037

Quarter Courses for Graduate Students Only

*Microbiology 300qc. Advanced Topics in Microbiology and Molecular Genetics
Catalog Number: 62986
David Lopes Cardozo (Medical School) 5995
A series of reading and discussion seminars, each running for a half term (7 weeks).
Note: Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 617-432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*Microbiology 301qc. Molecular Mechanisms of Microbial Pathogenesis
Catalog Number: 76052 Enrollment: Limited to 15.
Marcia Goldberg (Medical School) 3783 and Simon L. Dove (Medical School)
Quarter course (spring term). One 1.5 hour session weekly. Hours to be arranged .
During infection, microbial pathogens employ sophisticated mechanisms to enhance infection or dissemination. This course will focus on the recent literature on molecular mechanisms involved in bacteria pathogenesis during host-pathogen interactions.

*Microbiology 302qc. Introduction to Infectious Disease Research: Infectious Diseases Consortium Boot Camp
Catalog Number: 96439
Eric J. Rubin (Public Health) 4084
Quarter course (spring term). M. through F., 9-5.
This intensive January course provides an introduction to the breadth of infectious disease research carried out at Harvard. Students will learn techniques for studying infectious diseases, more about different types of infectious diseases, and meet faculty, students, and postdocs in infectious diseases labs at Harvard.

Neurobiology

The Program in Neuroscience offers multidisciplinary training in the neurosciences leading to the PhD degree. Course instruction and supervision of dissertation research is provided by faculty of the Department of Neurobiology at Harvard Medical School as well as faculty of other departments at Harvard Medical School (and its affiliated medical institutions) and the Faculty of Arts and Sciences.

Courses at the 200 level may be open to advanced undergraduates with permission of the instructor. Additional courses open to undergraduates are offered by the Neurobiology concentration, listed separately.

Primarily for Graduates

Neurobiology 200. Neurobiology
Catalog Number: 6062 Enrollment: Limited to 50.
John A. Assad (Medical School), Matthew P. Frosch (Medical School), Jeffrey Robb Holt (Medical School), Rosalind A. Segal (Medical School), and Ziv Williams (Medical School)
Half course (fall term). M., W., F., 9-12. EXAM GROUP: 10
This is a comprehensive course in Neuroscience. Basic principles of organization and function of the nervous system will be discussed with frequent reference to pathophysiology of neurological and psychiatric disorders. Combining pathophysiology with basic neuroscience should provide physician/scientists and Ph.D. candidates with a dynamic picture of the rapidly evolving field of neuroscience and the experimental process from which the picture is derived, and all students should emerge with a greater awareness both of the applications of their work in alleviating disease, and of the ways that disease can provide insight into basic scientific questions. The course will span modern neuroscience from molecular neurobiology to perception and cognition, and will include the following major topics: Anatomy and Development of the Brain; Cell Biology of Neurons and Glia; Ion Channels and Electrical Signaling; Synaptic Transmission, Integration, and Chemical Systems of the Brain; Sensory Systems, from Transduction to Perception; Motor Systems; and Higher Brain Function (Memory, Language, Affective Disorders).
Note: Offered jointly with the Medical School as HT 130. Follows the Medical School calendar. Nine hours of lecture or lab/conference weekly.
Prerequisite: Introductory cell and molecular biology course and permission of instructor.

Neurobiology 204. Neurophysiology of Central Circuits
Catalog Number: 5603
Rachel I. Wilson (Medical School), John A. Assad (Medical School), Richard T. Born (Medical School), Michael Tri Hoang Do (Medical School), Christopher D. Harvey (Medical School), Gabriel Kreiman (Medical School), and Margaret S. Livingstone (Medical School)
Half course (spring term). M., W., 10–12. EXAM GROUP: 5
This course introduces major themes and fundamental concepts underlying current research in systems neuroscience. Each week covers a different theme, and draws on research from different sensorimotor modalities and model organisms.
Note: Offered jointly with the Medical School as NB 721.0.
Prerequisite: Neurobiology 200 or with permission of instructor.

Neurobiology 207. Developmental Neurobiology
Catalog Number: 4977 Enrollment: Limited to 20.
Lisa V. Goodrich (Medical School), Michela Fagiolini (Medical School), Chenghua Gu (Medical School), and Beth Stevens (Medical School)
Half course (spring term). F., 10–12, W., 2–4. EXAM GROUP: 18
Advanced topics in nervous system development, including embryonic and adult neurogenesis, axon guidance, synapse development, and critical periods. Focus on current areas of investigation, unresolved questions, and common experimental approaches.
Note: Offered jointly with the Medical School as NB 720.0. Includes reading and discussion of primary literature aimed towards identifying important questions and developing a feasible research plan. The final exam consists of a grant proposal.
Prerequisite: Neurobiology 200 or with permission of instructor.

Neurobiology 209. Neurobiology of Disease
Catalog Number: 5562
Edward A. Kravitz (Medical School), Susanna Mierau (Medical School) and members of various clinical departments
Half course (spring term). M., 6-8:30., W., 7-9:30. EXAM GROUP: 13
Monday sessions involve patient presentations and “core” lectures describing clinical progression, pathology, and basic science underlying a major disease or disorder. Wednesdays, students present material from original literature sources, and there is general discussion.
Note: Given in alternate years. Offered jointly with the Medical School as NB 713.0. For advanced undergraduate, graduate students, MD and MD/PhD students.
Prerequisite: Introductory neurobiology, biochemistry, and genetics/molecular biology recommended.

*Neurobiology 220. Cellular Neurophysiology
Catalog Number: 2141
Bruce P. Bean (Medical School), Wade G. Regehr (Medical School), Bernardo L. Sabatini (Medical School), and Gary I. Yellen (Medical School)
Half course (fall term). Tu., Th., 9–12. EXAM GROUP: 9
Introduction to the physiology of neurons, focusing on using electrophysiology and imaging to study function of ion channels, generation of action potentials, and physiology of synaptic transmission. Includes problem sets and reading of original papers.
Note: Offered jointly with the Medical School as NB 714.0.
Prerequisite: Introductory neurobiology.

Neurobiology 221. Molecular Neurobiology
Catalog Number: 0443
Sandeep Robert Datta (Medical School), Jonathan B. Cohen (Medical School), Pascal Kaeser (Medical School), and Joshua M. Kaplan (Medical School)
Half course (spring term). Tu., Th., 10-12. EXAM GROUP: 12
Molecular biology and genetics of the nervous system. Emphasis on importance of ligand-receptor interactions and receptor regulation for the function of the nervous system and on the mechanisms of storage and release of neurotransmitters.
Note: Offered jointly with the Medical School as NB 715.0.
Prerequisite: Introductory neurobiology and molecular biology. Permission of the instructor required for undergraduates.

Neurobiology 230. Visual Object Recognition
Catalog Number: 78454
Gabriel Kreiman (Medical School)
Half course (fall term). M., 3:30–5:30. EXAM GROUP: 6
Examines how neuronal circuits represent information and how those circuits are implemented in artificial intelligence algorithms. Topics: architecture of visual cortex, neurophysiology, visual consciousness, computational neuroscience, models of pattern recognition and computer vision.
Prerequisite: Life Sciences 1a (or Life and Physical Sciences A) and Life Sciences 1b (or equivalent). Recommended: Math (Maa/Mab, Math 1A,1B, Math 19 a or equivalent). Physical Sciences 1. MCB 80.

Graduate Courses of Reading and Research

*Neurobiology 300. Advanced Topics in Neurobiology
Catalog Number: 6206
David Lopes Cardozo (Medical School) 5995 and members of the Department
Topics cover areas at the molecular, cellular, and systems levels in both basic and clinical neuroscience. A series of reading and discussion seminars, each running for a half term (seven weeks).
Note: Two seminars, which can be taken in different terms, are required for credit. Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 617-432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*Neurobiology 301. Visual Object Recognition: Computational Models and Neurophysiological Mechanisms
Catalog Number: 8402
Gabriel Kreiman (Medical School) 6174

*Neurobiology 302. Attention and Representation of Sensory Information in Cerebral Cortex
Catalog Number: 9850
John Maunsell (Medical School) 5670

*Neurobiology 303. Development, Function, and Disease State of the Inner Ear
Catalog Number: 0660
Zheng-Yi Chen (Medical School) 5478

*Neurobiology 304. Behavioral Genetic Studies of Aggression in Drosophila
Catalog Number: 5467
Edward A. Kravitz (Medical School) 2063

*Neurobiology 305. Cellular and Molecular Mechanisms of Epilepsy, Autism, and Postnatal Circuit Development
Catalog Number: 1349
Matthew Peter Anderson (Medical School ) 6691

*Neurobiology 306. The Molecular Mechanisms of How Neural and Vascular Networks are Coordinately Developed
Catalog Number: 0992
Chenghua Gu (Medical School) 5479

*Neurobiology 307. Architecture and plasticity of neurotransmitter release sites
Catalog Number: 77741
Pascal Kaeser (Medical School) 6467

*Neurobiology 308. Molecular Mechanisms of Catecholaminergic-specific Gene Regulation
Catalog Number: 6125
Kwang-Soo Kim (Medical School) 3046

*Neurobiology 309. Neural Circuitry in Schizophrenia
Catalog Number: 3823
Francine M. Benes (Medical School) 1869

*Neurobiology 310. Neural Coding of Chemosensory Stimuli
Catalog Number: 2408
Rachel I. Wilson (Medical School) 5257

*Neurobiology 311. Cellular and Molecular Studies of Synapse Formation in the Vertebrate Nervous System
Catalog Number: 0081
Joshua R. Sanes 5094

*Neurobiology 312. Study of synaptic competition by visualizing synaptic rearrangements directly in living animals using modern optical imaging techniques
Catalog Number: 0082
Jeff W. Lichtman 5163

*Neurobiology 313. Molecular Biology of Mammalian Circadian Clocks
Catalog Number: 1758
Charles J. Weitz (Medical School) 1139

*Neurobiology 314. Cellular Mechanism(s) of Axon Guidance
Catalog Number: 1742
Mustafa Sahin (Medical School) 6175

*Neurobiology 315. Neurotrophic Factors in Development: Functions and Mechanisms of Action
Catalog Number: 0128
Rosalind A. Segal (Medical School) 1564

*Neurobiology 316. The development, organization, and functions of sensory neurons that mediate touch
Catalog Number: 68038
David D. Ginty (Medical School) 7431

*Neurobiology 317. Molecular genetic dissection of circuit assembly and morphogenesis
Catalog Number: 4979
Lisa V. Goodrich (Medical School) 4771

*Neurobiology 317L. Identification of pre-markers of developmental dyslexia (DD) in the pre-reading and infant brain and the identification of the underlying neural mechanism of comorbidity of DD and ADHD
Catalog Number: 17626
Nadine Gaab (Medical School) 7430

*Neurobiology 318. Molecular Genetics of Cerebral Cortical Development
Catalog Number: 0825
Christopher A. Walsh (Medical School) 1560

*Neurobiology 319. Neurological Control of Cell Growth and Differentiation
Catalog Number: 2991
Michael E. Greenberg (Medical School) 1400

*Neurobiology 319L. Characterizing the molecular, neural circuit and ecological underpinnings of behavioral diversity in fruit flies
Catalog Number: 40312
Benjamin Lovegren de Bivort 7305

*Neurobiology 320. Neuroprotection and Neuronal Repair in Neurodegenerative Disease
Catalog Number: 4825
Ole S. Isacson (Medical School) 2077

*Neurobiology 320L. Neural circuits underlying cognitive behaviors in mice
Catalog Number: 31157
Christopher D. Harvey (Medical School) 6140

*Neurobiology 321. Visual Perception, Object Recognition, Higher Cognitive Functions, Vision and Art
Catalog Number: 5387
Margaret S. Livingstone (Medical School) 1064

*Neurobiology 321L (formerly *Neurobiology 321l). Multi-modal, multiscalar studies of human neurophysiology from single neurons to neuronal ensembles.
Catalog Number: 72929
Sydney S. Cash (Medical School) 7010

*Neurobiology 322. Cellular and Molecular Mechanisms in Axon Guidance and Regeneration
Catalog Number: 2873
Zhigang He (Medical School) 3910

*Neurobiology 322L. Molecular mechanisms of reward-related behavior
Catalog Number: 88657
Elena Halley Chartoff (Medical School) 7012

*Neurobiology 323. Synaptic Plasticity
Catalog Number: 3209
Florian Engert 4290

*Neurobiology 323L (formerly *Neurobiology 323l). Sensory Transduction in Hair Cells of the Mammalian Inner Ear
Catalog Number: 17369
Jeffrey Robb Holt (Medical School) 7023

*Neurobiology 324. Research in Neuropeptide Gene Regulation
Catalog Number: 4057
Joseph A. Majzoub (Medical School) 1875

*Neurobiology 324L. Neuroscience and Genetics of Human Variation in Reward and Self-Control
Catalog Number: 60914
Joshua William Buckholtz 1653

*Neurobiology 325. Synaptic Transmissions and Dendritic Processing
Catalog Number: 2065
Wade G. Regehr (Medical School) 1606

*Neurobiology 325L. Genetic dissection of inhibitory modulation in the central nervous system
Catalog Number: 51945
Uwe Rudolph (Medical School) 7049

*Neurobiology 326. Age-Dependent Mechanisms of Perinatal Brain Injury
Catalog Number: 2469
Frances E. Jensen (Medical School) 3940

*Neurobiology 326L. Extracellular matrix/neuron/glia interactions in the pathophysiology of schizophrenia and bipolar disorder
Catalog Number: 94951
Sabina Berretta (Medical School) 7087

*Neurobiology 327. Rotation Course in Neurosciences
Catalog Number: 5694
Richard T. Born (Medical School) 1787
Note: Primarily for students in Neuroscience.

*Neurobiology 327R. Lab Rotations in Neurosciences
Catalog Number: 23382
Richard T. Born (Medical School) 1787

*Neurobiology 328. Mechanisms of Cell Death in Stroke and Trauma
Catalog Number: 8967
Eng H. Lo (Medical School) 3049

*Neurobiology 328L. Role of Sleep in Memory and Emotional Processing in Healthy Subjects, Schizophrenia, Autism, and PTSD
Catalog Number: 65645
Robert A. Stickgold (Medical School) 3274

*Neurobiology 329. Molecular Mechanisms of Neurodegeneration in Alzheimer’s and Parkinsons Diseases
Catalog Number: 8816
Dennis J. Selkoe (Medical School) 2857

*Neurobiology 329L. The Genetic and Neural Basis of Sleep in Drosophila
Catalog Number: 28832
Dragana Rogulja (Medical School) 7133

*Neurobiology 330. Gene Expression in the Brain and Motivated Behavior
Catalog Number: 6269
William A. Carlezon (Medical School) 3929

*Neurobiology 330L. Translational Genomics of Parkinsons Disease: Cause, Cures, Diagnostics
Catalog Number: 55087
Clemens Scherzer (Medical School) 7131

*Neurobiology 331. Neural Differentiation, Regeneration and Stem Cell Regulation in the Brain and Eye
Catalog Number: 9045
Dong Feng Chen (Medical School) 3930

*Neurobiology 331L. Motivational Influences on Cortical Networks Underlying Attention, Learning and Memory of Sensory Cues
Catalog Number: 73341
Mark Lawrence Andermann (Medical School) 7130

*Neurobiology 332. Ligand-Gated Ion Channels: Structure and Function
Catalog Number: 1623
Jonathan B. Cohen (Medical School) 1120

*Neurobiology 332L. Biological and computational underpinnings of visual processing
Catalog Number: 96616
David Cox 7161

*Neurobiology 333. Intercellular Communication
Catalog Number: 2484
David L. Paul (Medical School) 2318

*Neurobiology 333L. Behavioral and synaptic plasticity in neuropsychiatric disorders; mechanisms of axon guidance and synapse elimination in autism
Catalog Number: 38811
Christopher William Cowan (Medical School) 7179

*Neurobiology 334. Hair Cells and Afferent Neurons of the Inner Ear
Catalog Number: 1134
Ruth Anne Eatock (Medical School) 5739

*Neurobiology 334L. Cellular and Molecular Mechanisms of Cortical Circuit Assembly
Catalog Number: 89186
Corey Harwell (Medical School) 7205

*Neurobiology 335. Physiological Function and the Pathogenetic Actions of Genes Implicated in Neurodegenerative Diseases
Catalog Number: 84752
Mark William Albers (Medical School) 7202

*Neurobiology 336. Developmental Cognitive Neuroscience, Focusing Primarily on Memory and Face Processing.
Catalog Number: 2242
Charles A. Nelson (Public Health) 5480

*Neurobiology 337. Neurobiology of the Human Circadian Pacemaker
Catalog Number: 5322
Charles A. Czeisler (Medical School) 7763

*Neurobiology 338. Neural Circuitry of Primate Visual Cortex
Catalog Number: 5634
Richard T. Born (Medical School) 1787

*Neurobiology 339. Mechanisms of Central Synaptic Transmission
Catalog Number: 9322
Vadim Bolshakov (Medical School) 4948

*Neurobiology 341. Cognition and Cognitive Disorders; the Role of Translational Regulation
Catalog Number: 8790
Raymond J. Kelleher (Medical School) 5740

*Neurobiology 342. Neurophysiology of Visual Cortex and LGN
Catalog Number: 2778
R. Clay Reid (Medical School) 2957

*Neurobiology 343. Neuronal Metabolism and Excitability; Molecular Physiology of Ion Channels
Catalog Number: 1887
Gary I. Yellen (Medical School) 3268

*Neurobiology 344. Neurobiology and protein biochemistry underlying Parkinson’s disease.
Catalog Number: 38211
Matthew James Lavoie (Medical School) 2640

*Neurobiology 345. Molecular Basis of Neuron Glia Interactions
Catalog Number: 4918
Gabriel Corfas (Medical School) 2907

*Neurobiology 346. Visual Processing in Primates
Catalog Number: 0184
John A. Assad (Medical School) 2985

*Neurobiology 347. Alzheimer’s Disease Research
Catalog Number: 6606
Bradley T. Hyman (Medical School) 2952

*Neurobiology 348. Neural stem cells and cerebrospinal fluid
Catalog Number: 11112
Maria Kristiina Lehtinen (Medical School) 6465

*Neurobiology 349. Olfactory and Vomeronasal Systems Molecular and Developmental Neurobiology
Catalog Number: 1416
Catherine Dulac 2801

*Neurobiology 350. Development, degeneration, and circuitry of the vertebrate retina
Catalog Number: 2038
Constance L. Cepko (Medical School) 1150

*Neurobiology 351. Neurogenetics of Disease
Catalog Number: 3008
Louis M. Kunkel (Medical School) 1330

*Neurobiology 353. Physiology, with an emphasis on ion channels, signal transduction, and imaging
Catalog Number: 3689
David E. Clapham (Medical School) 2987

*Neurobiology 354. Structural Biology of Signaling and Transport Through Biological Membranes
Catalog Number: 9454
Rachelle Gaudet 4413

*Neurobiology 355. A Biophysical Approach to System Function
Catalog Number: 33133
Michael Tri Hoang Do (Medical School) 6909

*Neurobiology 356. Ion Channels in Neural Cell Membranes
Catalog Number: 8368
David P. Corey (Medical School) 1345

*Neurobiology 357. Experience-Dependent Neuronal Circuit Maturation and Plasticity
Catalog Number: 6674
Michela Fagiolini (Medical School) 5751

*Neurobiology 358. Neurogenetics of Human Disease
Catalog Number: 7616
Xandra O. Breakefield (Medical School) 1428

*Neurobiology 359. Functional Characterization of Neural Circuits
Catalog Number: 23173
Sandeep Robert Datta (Medical School) 6518

*Neurobiology 360. Neural Signal Processing and Mechanisms of General Anesthesia
Catalog Number: 8525
Emery N. Brown (Medical School) 1399

*Neurobiology 361. Immunobiology of the Nervous System and its Tumors
Catalog Number: 7282
Lois A. Lampson (Medical School) 2491

*Neurobiology 362. Optical imaging in Alzheimer’s disease
Catalog Number: 5030
Brian Bacskai (Medical School) 6693

*Neurobiology 363. Axonal Development and Reorganization
Catalog Number: 7089
Larry I. Benowitz (Medical School) 3150

*Neurobiology 364. hypothalamic circuitry controlling sleep and circadian rhythms
Catalog Number: 1523
Clifford B. Saper (Medical School) 3394

*Neurobiology 365. Behavioral Pharmacology of Stimulant Drugs and Brain Dopamine Systems
Catalog Number: 8902
S. Barak Caine (Medical School) 5477

*Neurobiology 366. Functional Organization of the Retina
Catalog Number: 7391
Richard H. Masland (Medical School) 4923

*Neurobiology 367. Neocortical Development and Regeneration
Catalog Number: 4252
Jeffrey D. Macklis 3396

*Neurobiology 370. Genetic and Molecular Studies of Neurodegenerative Diseases
Catalog Number: 8336
Rudolph E. Tanzi (Medical School) 2683

*Neurobiology 371. Sensory Neuron Development and Sleep Using Genetics and Live Imaging in Zebrafish.
Catalog Number: 7081
Alexander F. Schier 5238

*Neurobiology 372. Neurotransmitter Control of Ion Channels
Catalog Number: 7104
Bruce P. Bean (Medical School) 1148

*Neurobiology 373. Developmental Studies of the Murine Trigeminal Sensory System
Catalog Number: 7485
Qiufu Ma (Medical School) 3034

*Neurobiology 374. Molecular Basis of Alzheimer’s Disease & Parkinson’s Disease
Catalog Number: 9022
Jie Shen (Medical School) 3059

*Neurobiology 375. Mechanisms of Synaptic Transmission & Plasticity
Catalog Number: 0790
Venkatesh N. Murthy 2424

*Neurobiology 376. Genetics of Neuronal Cell Biology
Catalog Number: 2911
Thomas L. Schwarz (Medical School) 3923

*Neurobiology 377. Physiological Studies of Phototransduction and Light Adaptation
Catalog Number: 6897
Clint L. Makino (Medical School) 3946

*Neurobiology 378. Neuronal Mechanisms and Animal Behavior
Catalog Number: 9659
Naoshige Uchida 5745 (on leave fall term)

*Neurobiology 379. Growth Factor Regulation of Neural Development and Oncogenesis
Catalog Number: 7751
Scott L. Pomeroy (Medical School) 3947

*Neurobiology 380. Functional Wiring of the Rabbit Retina, Control of Postnatal Development
Catalog Number: 4965
Elio Raviola (Medical School) 3582

*Neurobiology 381. Glutamate Transporters, Cell Death, Sleep/Wake Regulation
Catalog Number: 6912
Paul Allen Rosenberg (Medical School) 3949

*Neurobiology 382. Hypothalamus and Melanin Concentrating Hormone in the Regulation of Energy Homeostasis
Catalog Number: 1457
Eleftheria Maratos-Flier (Medical School) 4327

*Neurobiology 383. Role of the Basal Ganglia in Learning and Motivation
Catalog Number: 0492
Emad Eskandar (Medical School) 6176

*Neurobiology 384. Neuroscience of human emotions and emotional disorders
Catalog Number: 89733
Diego Pizzagalli (Medical School) 4425

*Neurobiology 385. Mammalian Gap Junctions, Inhibitory Neuronal Networks, and Corticothalamic Processing
Catalog Number: 1296
Carole Landisman (Medical School) 5787

*Neurobiology 386. Changes in Sensory Neurons that Contribute to Pain
Catalog Number: 7609
Clifford Woolf (Medical School) 3956

*Neurobiology 387. Development and Plasticity of Auditory Cortex
Catalog Number: 20829
Daniel B. Polley (Medical School) 6881

*Neurobiology 389. Molecular Regulation of Neural Tube Development
Catalog Number: 3914
Mary R. Loeken (Medical School) 3151

*Neurobiology 390. Mechanisms of Synapse Regulation
Catalog Number: 9202
Bernardo L. Sabatini (Medical School) 4300

*Neurobiology 391. The biology and experimental therapeutics of malignant brain tumors
Catalog Number: 12964
E. Antonio Chiocca (Medical School) 7429

*Neurobiology 392. Synaptic Plasticity in the CNS
Catalog Number: 6750
Chinfei Chen (Medical School) 4437

*Neurobiology 393. Genetic Disorders of Axon Growth and Guidance
Catalog Number: 3085
Elizabeth C. Engle (Medical School) 4312

*Neurobiology 394. Human Memory Processing and Brain State
Catalog Number: 23915
Edwin Malcolm Robertson (Medical School) 6565

*Neurobiology 395. Neuron-Glia Interactions During Development & Disease; Synapse Development & Plasticity; Neuro-Immune Interactions
Catalog Number: 7993
Beth Stevens (Medical School) 6678

*Neurobiology 396. Critical Period Mechanisms of Experience-Dependent Brain Development
Catalog Number: 0142
Takao K. Hensch (Medical School) 5813

*Neurobiology 397. Nervous System Construction and Function
Catalog Number: 0158
Samuel M. Kunes 3486

*Neurobiology 398. HSV Vectors for Cancer Therapy
Catalog Number: 4438
Samuel D. Rabkin (Medical School) 4772

*Neurobiology 399. Neurocircuits Thought to Regulate Metabolism and Behavior
Catalog Number: 5626
Bradford Barr Lowell (Medical School) 5741

Quarter Courses for Graduate Students Only

*Neurobiology 300qc. Advanced Topics in Neurobiology
Catalog Number: 11464
David Lopes Cardozo (Medical School) 5995
A series of reading and discussion seminars, each running for a half term (7 weeks).
Note: Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 617-432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*Neurobiology 301qc. Gene Therapy and Imaging for Nervous System Disorders
Catalog Number: 18456 Enrollment: Limited to 12.
Bakhos A. Tannous (Medical School) 6863, Xandra O. Breakefield (Medical School) 1428, Casey A. Maguire (Medical School) 7357, and Luk Hugo Vandenberghe (Medical School) 7356
Quarter course (fall term; repeated spring term). Tu., 3–5.
Introduction to gene therapy, different techniques in molecular imaging to monitor gene transfer and response to therapy. Discuss trends in gene therapy: viral vectors, siRNA and cell-based therapy, clinical trials for central nervous system disorders.

*Neurobiology 304qc. Regeneration and Repair in the Mammalian Nervous System: Cellular and Molecular Mechanisms
Catalog Number: 41092 Enrollment: Limited to 18.
Zhigang He (Medical School), Larry I. Benowitz (Medical School), Jeffrey D. Macklis, Clifford Woolf (Medical School)
Quarter course (spring term). W., 5:30–7:30 p.m.
Approaches toward mammalian neural regeneration, comparing and contrasting development with adult plasticity/repair. Overview lectures and discussion of primary literature, motivated by motor and sensory circuitry central to spinal cord injury, ALS, and peripheral nerve injury.
Note: Given in alternate years.

*Neurobiology 305qc. Biochemistry and Biology of Neurodegenerative Diseases
Catalog Number: 22489 Enrollment: Limited to 20.
Dominic M. Walsh (Medical School) 7516 and Michael S. Wolfe (Medical School) 4543
Quarter course (fall term). Tu., 3:30–5:30.
Biochemistry and biology are integrated to provide a broad perspective on major human neurodegenerative diseases. The biochemistry, enzymology, structural biology and pathology of disease-associated proteins and approaches to developing therapeutics will be examined.
Note: Expected to be given in the second quarter of the fall term of 2014-2015.

*Neurobiology 306qc. Quantitative Methods for Biologists
Catalog Number: 85319 Enrollment: Limited to 80.
Michael Springer, Richard T. Born (Medical School)
Quarter course (fall term; repeated spring term). Hours to be arranged .
The goals of this course are to introduce students to programming in the MATLAB environment and to begin using this tool for analyzing data and for gaining intuition about the behavior of complex systems through the use of numerical simulations.

*Neurobiology 307qc. Molecular Causes of Congenital Defects of the CNS
Catalog Number: 93018 Enrollment: Limited to 12.
Mary R. Loeken (Medical School) 3151
Quarter course (spring term). Tu., 2–5.
Congenital defects can be caused by inheritance of a defective gene, maternal infection, or prenatal exposure to environmental teratogens. Use of mutant mouse strains and genomic sequencing have been particularly useful in the rapid proliferation of our understanding of the cellular and molecular mechanisms by which congenital defects of the brain or nervous system arise, and how they lead to functional consequences that range from biochemical abnormalities to gross structural defects.
Note: Given every three years.

*Neurobiology 309qc. The molecular pathology and current therapies for retinal diseases
Catalog Number: 42626
Dong Feng Chen (Medical School) 3930
Quarter course (fall term). Hours to be arranged.
Note: Offered in alternate years.

Pharmacology

For courses pertaining to Pharmacology see listings under the Department of Biological Chemistry and Molecular Pharmacology.

Speech and Hearing Bioscience and Technology

Primarily for Graduates

SHBT 200. Acoustics of Speech and Hearing
Catalog Number: 60388 Enrollment: Limited to 20. Must have a minimum of 5 students
John J. Rosowski (Medical School) and Christopher A. Shera (Medical School)
Half course (fall term). W., at 12, Tu., Th., 1–2:30. EXAM GROUP: 8
Discusses limitations that the speech production and hearing systems impose on the sounds we produce and sense. Focuses on acoustic cues used in sound localization, speech production mechanisms, the mechanics of sound reception and perception.
Note: This course is taught in consort with 6.551J/HST.714J at the Massachusetts Institute of Technology. Classes will be held at MIT.
Prerequisite: Mathematical methods in science (Applied Mathematics 21a or Mathematics 21a) or equivalent. Rigid body mechanics (Physics 11A), or electrical circuits (Engineering Science 154) or permission of the instructor

SHBT 201. Biology of the Inner Ear
Catalog Number: 75495 Enrollment: Limited to 12.
M. Charles Liberman (Medical School) and Stephane Maison (Medical School)
Half course (fall term). Tu., Th., 9–10:30, F. laboratory hours to be arranged. EXAM GROUP: 9
Normal biology, biophysics, physiology and morphology of the inner ear, its sensory innervation and efferent control systems, and the mechanisms underlying sensorineural hearing loss and balance disorders. Material is presented through lectures, laboratory exercises and discussions of the primary literature.
Prerequisite: Introductory neurobiology recommended

SHBT 202. Clinical Aspects of Hearing and Speech
Catalog Number: 69294 Enrollment: Limited to 15. Minimum of 5
Joseph B. Nadol (Medical School and MEEI) and Konstantina Stankovic (Medical School and MEEI)
Half course (spring term). M., W., 5–7. Clinical observations Mon-Fri 8-3. EXAM GROUP: 13
Clinical approach to speech and hearing disorders as practiced by physicians, audiologists, speech clinicians, rehabilitation specialists, bioengineers. Includes observation of patient care in clinic and operating room, audiology/balance disorders experience, lectures and discussion groups.
Note: Offered jointly with HST 724 at MIT. Classes to be held at the Massachusetts Eye and Ear Infirmary (MEEI)
Prerequisite: Anatomy of Speech and Hearing, Acoustics of Speech and Hearing or permission of the course director

*SHBT 203. Anatomy of Speech and Hearing
Catalog Number: 17772 Enrollment: Limited to 12.
Barbara C. Fullerton (Medical School), James Tracey Heaton (Medical School), and James Bradley Kobler (Medical School)
Half course (spring term). Lecture: M.- F., 9:30- 10:30., Lab: M.- F., 10:30-1:30. EXAM GROUP: 10
This course covers anatomy of the head and neck, with cadaver dissection, stressing structures important in speech and hearing. Lecture topics also include basic neuroanatomy, imaging, surgery, and cancer of head and neck.
Note: This an intensive January Course. Offered jointly with MIT as HST 718. Classes to be held at the Harvard Medical School campus (HMS)
Prerequisite: Introductory biology or equivalent and permission of the course director.

SHBT 204. Speech Communication
Catalog Number: 47986 Enrollment: Limited to 20.
Robert E. Hillman (Medical School) and other faculty
Half course (spring term). Tu., Th., 11–12:30. EXAM GROUP: 15
Survey of human speech communication. Acoustic theory of speech production; physiologic and acoustic descriptions of phonetic features, prosody, voice and speech perception and speech motor control. Applications to recognition, synthesis and speech disorders.
Note: Offered jointly with MIT course HST.710. Classes to be held at MIT.
Prerequisite: Background equivalent to MIT HST.714.

SHBT 205. Neural Coding and Perception of Sound
Catalog Number: 63093 Enrollment: Limited to 20.
Bertrand Delgutte (Medical School), M. Christian Brown (Medical School), John J. Guinan (Medical School), Jennifer R. Melcher (Medical School), and Daniel B. Polley (Medical School)
Half course (spring term). M., W., 9:30–11:30, Occasional lab on Friday. EXAM GROUP: 10
Neural structures and mechanisms mediating the detection, localization and recognition of sounds. General principles are conveyed by theme discussions of auditory masking, sound localization, musical pitch, cochlear implants, cortical plasticity and auditory scene analysis.
Note: Offered jointly with MIT HST.723J.
Prerequisite: Neurobiology 200 or Permission of the instructor.

SHBT 206 (formerly Pathology 205). Molecular Biology of the Auditory System
Catalog Number: 0211
Albert Edge (Medical School)
Half course (fall term). Tu., 4–6. EXAM GROUP: 16
Advances in molecular biology of hearing. Topics: Transcriptional and post-translational regulation of gene expression; cell fate determination during inner ear development; inner ear stem cells and regenerative capacity in various species; use of genomics in investigations of the inner ear; critical genes for generating functional hair cells.
Note: Given in alternate years.
Prerequisite: Introductory courses in neurobiology and molecular biology are recommended.

Graduate Courses of Reading and Research

*SHBT 300. Auditory neural coding laboratory
Catalog Number: 29629
Bertrand Delgutte (Medical School) 6509
Research projects on the neural coding of sound and the neural basis of auditory perception, with emphasis on the mechanisms for listening in adverse environments comprising reverberation and competing sound sources.

*SHBT 301. Investigates the acoustics and mechanics of the middle ear, with a dual emphasis on comparative physiology of the ear and clinical issues in middle-ear disease and its treatment
Catalog Number: 54684
John J. Rosowski (Medical School) 6498

*SHBT 302. The mechanics and physiology of the peripheral auditory system, with an emphasis on mechanisms of cochlear amplification, nonlinearity, and otoacoustic emissions.
Catalog Number: 55476
Christopher A. Shera (Medical School) 6499

*SHBT 303. Sensory coding, and feedback control, in the mammalian cochlea; mechanisms of sensorineural hearing loss.
Catalog Number: 42465
M. Charles Liberman (Medical School) 3945

*SHBT 305. Degeneration and regeneration of the auditory nerve; biomarkers of sensorineural hearing loss
Catalog Number: 17641
Konstantina Stankovic (Medical School) 6500

*SHBT 306. Clinical studies of laryngeal voice disorders with an emphasis on the development of improved diagnostic and treatment methods including the application of acoustic, aerodynamic, mechanical and imaging technologies.
Catalog Number: 16069
Robert E. Hillman (Medical School) 6508

*SHBT 310. Independent Study in Speech and Hearing Sciences
Catalog Number: 76933
John J. Rosowski (Medical School) 6498 and Bertrand Delgutte (Medical School) 6509
Opportunity for independent study of topics in speech and hearing sciences under regular supervision by an SHBT faculty member.
Note: For SHBT students only

*SHBT 311. Clinical work at MGHIHP
Catalog Number: 85325
Instructor to be determined (fall term); John J. Rosowski (Medical School) 6498 (spring term only)
Note: For SHBT students only.

*SHBT 330. Dissertation Research
Catalog Number: 45552
John J. Rosowski (Medical School) 6498
Half course (spring term). .
For SHBT graduate students studying in research labs at MIT only.

*SHBT 333r. Laboratory Rotation in Speech and Hearing Sciences
Catalog Number: 41383
Bertrand Delgutte (Medical School) 6509
Research on topics in theoretical, experimental, clinical, or translational aspects of Speech and Hearing Sciences arranged on an individual basis with a research supervisor.
Note: For SHBT students only

Quarter Courses for Graduate Students Only

*SHBT 301qc. Speech and Hearing Laboratory Visits
Catalog Number: 14124
Bertrand Delgutte (Medical School) 6509
Research on topics in theoretical, experimental, clinical, or translational aspects of Speech and Hearing Sciences arranged on an individual basis with a research supervisor.

Virology

Primarily for Graduates

*Virology 200. Introduction to Virology
Catalog Number: 6075 Enrollment: Limited to 20.
Max L. Nibert (Medical School), Michaela Gack (Medical School), Elliott D. Kieff (Medical School), David M. Knipe (Medical School), Karl Münger (Medical School), and Priscilla Yang (Medical School)
Half course (fall term). M., W., 1:30-3:30. EXAM GROUP: 1
Introduction to virology. The lecture component reviews the basic principles of virology and introduces the major groups of human viruses. Weekly discussion groups critically analyze selected papers from the literature.
Note: There will be a final project consisting of a proposal based on laboratory rotations (for Virology, BBS, or Immunology Program students) or a final paper based on a topic from the literature. Offered jointly with the Medical School as MG 705.0.

Virology 201. Virology
Catalog Number: 1190
Sean P.J. Whelan (Medical School), James M. Cunningham (Medical School), and Michaela Gack (Medical School)
Half course (spring term). M., W., 2–3:30. EXAM GROUP: 18
Literature based reading. Proposal writing. Course covers a broad range of topics: viral genetics, structure/replication, pathogenesis, evolution ("emerging viruses"), chronic infection, latency, innate and adaptive immunity, anti-viral drugs and vaccine strategies.
Note: Offered jointly with the Medical School as MG 723.0.
Prerequisite: Graduate standing and permission required.

Virology 202. Proposal Writing
Catalog Number: 6025
Michaela Gack (Medical School), Todd Allen (Medical School), Galit Alter (Medical School), Samuel D. Rabkin (Medical School), and Frederick C. Wang (Medical School)
Half course (fall term). W., 1:30–4:45. EXAM GROUP: 1
Students will write, present, and evaluate research proposals in the areas of virus replication, viral pathogenesis and treatment and prevention of viral infections.
Note: Offered jointly with the Medical School as MG 724.0.
Prerequisite: General background in biochemistry and virology.

Graduate Courses of Reading and Research

*Virology 300r. Introduction to Research
Catalog Number: 0530
David M. Knipe (Medical School) 7089

*Virology 301. Herpes Virus Interaction with the Host Cell
Catalog Number: 7344
David M. Knipe (Medical School) 7089

*Virology 303. AIDS Pathogenesis Research in the Nonhuman Primate Model of SIV Infection with a Focus on Host Immune Responses in Natural Hosts of SIV, AIDS Vaccine Development, and Immunopathogenesis of CMV Infection
Catalog Number: 6772
Amitinder Kaur (Medical School) 6692

*Virology 304. Molecular Biology of Kaposi’s Sarcoma-Associated Herpes Virus
Catalog Number: 8182
Kenneth M. Kaye (Medical School) 3064

*Virology 305. Entry and Replication of Negative-Strand RNA Viruses
Catalog Number: 5437
Sean P.J. Whelan (Medical School) 4591

*Virology 307. Genetics and Biochemistry of Prokaryotic Transposable Elements and Yeast Meiotic Chromosome Metabolism
Catalog Number: 6097
Nancy Kleckner 4697 (on leave spring term)

*Virology 308. Molecular Genetics of Herpes Virus
Catalog Number: 3000
Donald M. Coen (Medical School) 7617

*Virology 309. Immunology of Pregnancy, Tolerance and Multiple Sclerosis
Catalog Number: 4011
Jack L. Strominger 1193

*Virology 310. Cellular Transformation by SV40
Catalog Number: 0221
James A. DeCaprio (Medical School) 1296

*Virology 311. Molecular Biology of Epstein-Barr Infection
Catalog Number: 0513
Frederick C. Wang (Medical School) 1297

*Virology 312. Molecular Biology of Epstein Barr Virus infection and Transformation of B Lymphocytes
Catalog Number: 3483
Elliott D. Kieff (Medical School) 1858

*Virology 313. Molecular Basis for Simian Virus Pathogenesis
Catalog Number: 2528
Ronald C. Desrosiers (Medical School) 1874

*Virology 314. Viral Oncoproteins as Probes to Study the Regulation of Cell Growth and Differentiation
Catalog Number: 6286
Karl Münger (Medical School) 1586

*Virology 315. Mechanisms of Transcriptional Repression in Eukaryotic Cells
Catalog Number: 0462
Yang Shi (Medical School) 3169

*Virology 317. Virology and Immunology of Human Retroviruses
Catalog Number: 0954
Myron Essex (Public Health) 2499

*Virology 318. Persistence and Pathogenesis of Hepatitis C Virus Infection
Catalog Number: 9144
Raymond Taeyong Chung (Medical School) 6178

*Virology 319. Functional Analysis of Tumor Suppression Genes
Catalog Number: 5817
David Morse Livingston (Medical School) 4872

*Virology 320. Pathogenesis of Human Retroviruses
Catalog Number: 1532
Joseph G. Sodroski (Public Health) 1712

*Virology 321. Retroviral DNA Integration
Catalog Number: 6857
Alan N. Engelman (Medical School) 2196

*Virology 322. HIV Molecular Biology and Pathogenesis
Catalog Number: 9023
Dana Gabuzda (Medical School) 1581

*Virology 323. Immunobiology of Epstein-Barr Virus Receptor; Pathogenesis of EBV and B-cell tumors
Catalog Number: 69778
Joyce D. Fingeroth (Medical School) 2707

*Virology 324. Leukemogenic Retroviruses
Catalog Number: 5263
James M. Cunningham (Medical School) 2346

*Virology 325. Retroviral Pathogenesis; AIDS Vaccine Development, and the Nature of Protective Immunity
Catalog Number: 8029
Ruth M. Ruprecht (Medical School) 2716

*Virology 326. Pathogenesis and Treatment of Human Retrovirus and Herpesvirus Infection
Catalog Number: 6440
Martin S. Hirsch (Medical School) 2876

*Virology 328. Humoral Response to Retroviral Infections in Humans; Identification of Coding Sequence of Human Retroviruses and their Gene Products
Catalog Number: 2513
Tun-hou Lee (Public Health) 2769

*Virology 329. Immune control of HIV and implications for vaccine development
Catalog Number: 5417
Bruce Walker (Medical School) 2847

*Virology 330. Critical Readings in Virology
Catalog Number: 5966
David Lopes Cardozo (Medical School) 5995
A series of reading and discussion seminars, each running for a half term (seven weeks). Different topics are covered each term.
Note: Two seminars, which can be taken in different terms, are required for credit. Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 617-432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*Virology 331. Polyomavirus JC, the Etiologic Agent of Progressive Multifocal Eukoencephalopathy (PML)
Catalog Number: 9476
Igor J. Koralnik (Medical School) 6179

*Virology 332. Protein Phosphorylation and Gene Expression in Normal and Transformed Cells
Catalog Number: 9093
Raymond L. Erikson 7506

*Virology 333. Antiretroviral Drug Resistance, and Drug Resistant Human Immunodeficiency Virus
Catalog Number: 5526
Daniel R. Kuritzkes (Medical School) 4773

*Virology 336. Genetic Changes in HIV and Hepatitis C Virus
Catalog Number: 8685
Todd Allen (Medical School) 6180

*Virology 339. Mechanisms of HIV protein degradation, epitope processing and presentation to virus-specific CD8 T cells
Catalog Number: 3999
Sylvie Le Gall (Medical School) 6269

*Virology 347. Reovirus Structure, Assembly, and Particle Functions in Entry and RNA Synthesis
Catalog Number: 4181
Max L. Nibert (Medical School) 3896

*Virology 348. Immunopathogenesis of HIV-1 and the Development of HIV-1 Vaccine Strategies
Catalog Number: 8409
Dan Hung Barouch (Medical School) 5744

*Virology 349. Imaging Techniques to Study the Behavior of Individual Biological Molecules and Complexes in Vitro and in Live Cells
Catalog Number: 33202
Xiaowei Zhuang 3991

*Virology 350. Regulation of Host Innate Immunity Against Viral Infection
Catalog Number: 50408
Michaela Gack (Medical School) 6959

*Virology 351. molecular mechanisms of HIV (human immunodeficiency virus) viral entry
Catalog Number: 29818
Bing Chen (Medical School) 7013

*Virology 352. Biology and evolution of human adenoviruses.
Catalog Number: 52819
James Chodosh (Medical School) 7017

Quarter Courses for Graduate Students Only

*Virology 300qc. Advanced Topics in Virology
Catalog Number: 78093
David Lopes Cardozo (Medical School) 5995
A series of reading and discussion seminars, each running for a half term (7 weeks).
Note: Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 617-432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*Virology 301qc. Advanced Topics in Virology - Viral Oncology
Catalog Number: 33563
Karl Munger (Medical School) 1586, James DeCaprio (Medical School)
Quarter course (spring term). Tu., Th., 4:30-6:00.
Introduction to viral oncology and critical evaluation of key papers in viral oncology. Requirements include presentations, written critiques and class participation.
Note: Offered in the month of January; class size limited to 10 students